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Evaluation of Serum Ischemia Modified Albumin Levels in Acute Rheumatic Fever Before and After Therapy

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Abstract

Objective

To investigate ischemia modified albumin (IMA) levels in children with acute rheumatic fever (ARF) before and after therapy and compare them with those of controls.

Methods

Twenty seven patients with ARF and 18 healthy, age and sex matched children were included in the study. The diagnosis of ARF was established according to the modified Jones criteria. Follow-up studies were made when acute phase reactants [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)] levels returned normal. IMA levels were measured using the rapid and colorimetric method with the albumin cobalt binding test.

Results

IMA levels were significantly higher in ARF group (p < 0.001) compared with controls at the time on admission. IMA (absorbance units) was measured as 0.41 ± 0.10 in the control group, 0.55 (0.44–1.13) in the study group before treatment and 0.48 ± 0.12 in the study group after treatment. After treatment, statistically important decrements were determined in the levels of ESR (p<0.001), CRP (p<0.001) and IMA (p<0.01). There was no significant difference for IMA levels between after treatment and control group. IMA levels at the time on admission correlated positively with ESR (r = 0.605, p < 0.01) and CRP (r = 0.543, p < 0.01).

Conclusions

The present study shows that increased serum IMA levels in patients with ARF at the time of diagnosis is a sign of increased inflammation. Thus, serum IMA levels may be used as a follow-up marker like CRP and ESR for evaluating the efficacy of treatment in ARF.

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Acknowledgments

This study is partly present as a poster in 46th Annual Meeting of the Association for European Paediatric and Congenital Cardiology in Istanbul-Turkey at 23–26 May 2012.

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Authors and Affiliations

  1. Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey

    Aysun Toker & Humeyra Cicekler

  2. Department of Pediatric Cardiology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey

    Zehra Karatas, Hakan Altın, Sevim Karaarslan & Hayrullah Alp

  3. Department of Pediatric Cardiology, Bolu Izzet Baysal State Hospital, Bolu, Turkey

    Zehra Karatas

Authors
  1. Aysun Toker
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  2. Zehra Karatas
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  3. Hakan Altın
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  4. Sevim Karaarslan
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  5. Humeyra Cicekler
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  6. Hayrullah Alp
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Correspondence to Zehra Karatas.

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Toker, A., Karatas, Z., Altın, H. et al. Evaluation of Serum Ischemia Modified Albumin Levels in Acute Rheumatic Fever Before and After Therapy. Indian J Pediatr 81, 120–125 (2014). https://doi.org/10.1007/s12098-013-1092-x

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  • DOI: https://doi.org/10.1007/s12098-013-1092-x

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