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5 α-Reductase Type 2 Deficiency: Response to Dihydrotestosterone Gel

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Abstract

5α-reductase (5α-R) deficiency is an important cause of ambiguious genitalia in genetic males; however therapeutic experience in literature is limited. In this report authors describe a child with 46 XY Disorder of Sexual Differentiation (DSD), due to 5α-reductase deficiency, who was managed with Dihydrotestosterone (DHT) gel.

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Acknowledgements

The authors gratefully acknowledge the helpful suggestions of Prof. Olaf Hiort, Germany in the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Endocrinology, Konaseema Institute of Medical Sciences, Amalapuram, India

    Madhavarao Vupputuri

  2. Department of Pediatrics, Rangaraya Medical College, Kakinada, India

    Madhurima Kandepu

  3. Devireddy Diabetes and Hormone Centre, Kadapa, India

    Harikishore Reddy Devireddy

  4. GIDE Hospital, 1st floor, Pydah plaza, Salipeta, Kakinada, AP 533001, India

    Madhavarao Vupputuri

Authors
  1. Madhavarao Vupputuri
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  2. Madhurima Kandepu
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  3. Harikishore Reddy Devireddy
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Correspondence to Madhavarao Vupputuri.

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Vupputuri, M., Kandepu, M. & Devireddy, H.R. 5 α-Reductase Type 2 Deficiency: Response to Dihydrotestosterone Gel. Indian J Pediatr 81, 821–823 (2014). https://doi.org/10.1007/s12098-013-1032-9

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  • DOI: https://doi.org/10.1007/s12098-013-1032-9

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