Abstract
Nephrotic syndrome (NS) is the most common glomerular disorder of childhood and a leading cause of pediatric renal failure; however the etiology of NS remains largely unknown. Recent reports demonstrating that an anti-CD20 antibody can induce remission of NS strongly suggest a potentially novel role for B cells in NS pathogenesis. In this report, the authors investigated B cell cytokine profiles following in vitro stimulation in a monozygotic twin pair discordant for NS. The results revealed that clear differences in the cytokine profiles of B cells exist between the patient and the unaffected twin. This is the first report of altered B lymphocyte responses among a monozygotic twin pair that is discordant for NS. Future studies are needed to identify cytokine differences that track with NS relapse and/or NS response to therapy.
This is a preview of subscription content, log in via an institution to check access.
References
Shalhoub RJ. Pathogenesis of lipoid nephrosis: A disorder of T-cell function. Lancet. 1974;2:556–60.
Guven AG, Akman S, Bahat E, et al. Rapid decline of anti-pneumococcal antibody levels in nephrotic children. Pediatr Nephrol. 2004;19:61–5.
van Husen M, Kemper MJ. New therapies in steroid-sensitive and steroid-resistant idiopathic nephrotic syndrome. Pediatr Nephrol. 2011;26:881–92.
Anolik JH, Looney RJ, Lund FE, Randall TD, Sanz I. Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets. Immunol Res. 2009;45:144–58.
Duddy ME, Alter A, Bar-Or A. Distinct profiles of human B cell effector cytokines: A role in immune regulation? Immunol. 2004;172:3422–7.
Lund FE. Cytokine-producing B lymphocytes-key regulators of immunity. Curr Opin Immunol. 2008;20:332–8.
Evans JG, Chavez-Rueda KA, Eddaoudi A, et al. Novel suppressive function of transitional 2 B cells in experimental arthritis. J Immunol. 2007;178:7868–78.
Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM. B cells regulate autoimmunity by provision of IL-10. Nat Immunol. 2002;3:944–50.
Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med. 2003;197:489–501.
Duddy M, Niino M, Adatia F, et al. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol. 2007;178:6092–9.
Conflict of Interest
None.
Role of Funding Source
This study was funded by University of Medicine and Dentistry of New Jersey (UMDNJ) Foundation.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Valentin-Acevedo, A., Covey, L.R. & Gurkan, S. B Lymphocyte Cytokine Profile in a Monozygotic Twin Pair Discordant for Nephrotic Syndrome. Indian J Pediatr 80, 875–877 (2013). https://doi.org/10.1007/s12098-013-0984-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-013-0984-0