Abstract
Pediatric hypertension is usually secondary to an underlying identifiable cause, most often renal. Hypertension with low Plasma Rennin Activity (PRA), although rare, is important as it is often familial and is associated with single gene disorders (monogenic). It hence carries greater genetic implications for the family. The authors’ hereby report a case of low PRA hypertension which was diagnosed as Liddle Syndrome, an autosomal dominant form of hereditary hypertension. Early detection and appropriate treatment may help to improve the long term morbidity and mortality in children with this condition.
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References
Grinsell MM, Norwood VF. At the bottom of the differential diagnosis list: unusual causes of pediatric hypertension. Pediatr Nephrol. 2009;24:2137–46.
Assadi FK, Kimura RE, Subramanian U, Patel S. Liddle syndrome in a newborn infant. Pediatr Nephrol. 2002;17:609–11.
Liddle GW, Bledsoe T, Coppage WS. A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans Am Assoc Phys. 1963;76:199–213.
Shimkets RA, Warnock DG, Bositis CM, et al. Liddle’s syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell. 1994;79:407–14.
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Sinha, R., Salphale, I. & Agarwal, I. A Case of Liddle Syndrome. Indian J Pediatr 80, 878–880 (2013). https://doi.org/10.1007/s12098-012-0951-1
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DOI: https://doi.org/10.1007/s12098-012-0951-1