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Prevalence and Risk Factors for Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus in Transfused Children in Kinshasa

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To determine seroprevalence of hepatitis C virus (HCV), human immunodeficiency virus (HIV), and hepatitis B virus (HBV) and associated factors among transfused children.


A multicenter cross-sectional study of transfused children aged between 18 mo and 13 y old was conducted in 4 hospitals in Kinshasa. Blood samples were collected for the detection of Hepatitis B surface antigen (HBsAg) and antibodies to HCV, HIV 1and 2.


A total of 177 (47.7 %) boys and 194 (52.3 %) girls participated in the study. The median age was 59.5 mo (Interquartile range IQR = 60.6). The prevalence rates of HCV, HBV, and HIV infection were 13.5 %, 1.6 %, and 1.3 %, respectively. Frequency of transfusion events were significantly associated with HCV (p < 0.001) and HIV (p < 0.05) infections.


HCV infection was by far more frequently identified than HBV and HIV infections among Congolese transfused children. Frequency of transfusion events was the only significant risk factor associated with HCV and HIV infections but not for HBV.

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  1. Dhingra N, Hafner V. Safety of blood transfusion at the international level: the role of WHO. Transfus Clin Biol. 2006;13:200–2.

    Article  PubMed  CAS  Google Scholar 

  2. Cunha L, Plouzeau C, Ingrand P, et al. Use of replacement blood donors to study the epidemiology of major blood-borne viruses in the general population of Maputo, Mozambique. J Med Virol. 2007;79:1832–40.

    Article  PubMed  Google Scholar 

  3. Tapko J, Sam O, Diarra-Nama A. Status of blood safety in the WHO African region: report of the 2004 survey. 2007

  4. Bates I, Manyasi G, Medina Lara A. Reducing replacement donors in Sub-Saharan Africa: challenges and affordability. Transfus Med. 2007;17:434–42.

    Article  PubMed  CAS  Google Scholar 

  5. Marcucci C, Madjdpour C, Spahn DR. Allogeneic blood transfusions: benefit, risks and clinical indications in countries with a low or high human development index. Br Med Bull. 2004;70:15–28.

    Article  PubMed  Google Scholar 

  6. Allain JP. Transfusion risks of yesterday and of today. Transfus Clin Biol. 2003;10:1–5.

    Article  PubMed  Google Scholar 

  7. Ocak S, Kaya H, Cetin M, Ozturk M. Seroprevalence of hepatitis B and hepatitis C in patients with thalassemia and sickle cell anemia in a long-term follow-up. Arch Med Res. 2006;37:895–8.

    Article  PubMed  Google Scholar 

  8. Covas DT, Boturao Neto E, Zago MA. The frequency of blood-born viral infections in a population of polytransfused Brazilian patients. Rev Inst Med Trop Sao Paulo. 1993;35:271–3.

    Article  PubMed  CAS  Google Scholar 

  9. Schmunis GA, Cruz JR. Safety of the blood supply in Latin America. Clin Microbiol Rev. 2005;18:12–29.

    Article  PubMed  Google Scholar 

  10. Schmunis GA, Zicker F, Pinheiro F, Brandling-Bennett D. Risk for transfusion-transmitted infectious diseases in Central and South America. Emerg Infect Dis. 1998;4:5–11.

    Article  PubMed  CAS  Google Scholar 

  11. Tshilolo LM, Mukendi RK, Wembonyama SO. Blood transfusion rate in Congolese patients with sickle cell anemia. Indian J Pediatr. 2007;74:735–8.

    Article  PubMed  CAS  Google Scholar 

  12. Shaffer N, Hedberg K, Davachi F, et al. Trends and risk factors for HIV-1 seropositivity among outpatient children, Kinshasa, Zaire. AIDS. 1990;4:1231–6.

    Article  PubMed  CAS  Google Scholar 

  13. Bloch EM, Vermeulen M, Murphy E. Blood transfusion safety in Africa: a literature review of infectious disease and organizational challenges. Transfus Med Rev. 2012;26:164–80.

    Article  PubMed  Google Scholar 

  14. Calderón GM, González-Velázquez F, González-Bonilla CR, et al. Prevalence and risk factors of hepatitis C virus, hepatitis B virus, and human immunodeficiency virus in multiply transfused recipients in Mexico. Transfusion. 2009;49:2200–7.

    Article  PubMed  Google Scholar 

  15. Moore A, Herrera G, Nyamongo J, et al. Estimated risk of HIV transmission by blood transfusion in Kenya. Lancet. 2001;358:657–60.

    Article  PubMed  CAS  Google Scholar 

  16. Ministry of Plan. Enquete Demographique et de santé EDS-RDC 2007. Democratic Republic of Congo. Final report, Kinshasa. 2008.

  17. Programme National Multisectoriel de Lutte contre le SIDA (PNMLS). Rapport National de suivi de la declaration d’engagement UNGASS, Kinshasa. 2010.

  18. HIV infection diagnostic strategy by WHO, National AIDS program (PNLS). 2007.

  19. Candotti D, Allain J-P. Transfusion-transmitted hepatitis B virus infection. J Hepatol. 2009;551:798–809.

    Article  Google Scholar 

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Role of Funding Source

The National Blood Center (CNTS) supported in part this study and main authors also supported the study. No external funding.

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Correspondence to A. M. Ngoma.

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Katabuka, M., Mafuta, M.E., Ngoma, A.M. et al. Prevalence and Risk Factors for Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus in Transfused Children in Kinshasa. Indian J Pediatr 80, 659–662 (2013).

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