Prevalence and Risk Factors for Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus in Transfused Children in Kinshasa
To determine seroprevalence of hepatitis C virus (HCV), human immunodeficiency virus (HIV), and hepatitis B virus (HBV) and associated factors among transfused children.
A multicenter cross-sectional study of transfused children aged between 18 mo and 13 y old was conducted in 4 hospitals in Kinshasa. Blood samples were collected for the detection of Hepatitis B surface antigen (HBsAg) and antibodies to HCV, HIV 1and 2.
A total of 177 (47.7 %) boys and 194 (52.3 %) girls participated in the study. The median age was 59.5 mo (Interquartile range IQR = 60.6). The prevalence rates of HCV, HBV, and HIV infection were 13.5 %, 1.6 %, and 1.3 %, respectively. Frequency of transfusion events were significantly associated with HCV (p < 0.001) and HIV (p < 0.05) infections.
HCV infection was by far more frequently identified than HBV and HIV infections among Congolese transfused children. Frequency of transfusion events was the only significant risk factor associated with HCV and HIV infections but not for HBV.
KeywordsHepatitis C virus Human immunodeficiency virus Hepatitis B virus Transfusion Children
- 3.Tapko J, Sam O, Diarra-Nama A. Status of blood safety in the WHO African region: report of the 2004 survey. 2007Google Scholar
- 16.Ministry of Plan. Enquete Demographique et de santé EDS-RDC 2007. Democratic Republic of Congo. Final report, Kinshasa. 2008.Google Scholar
- 17.Programme National Multisectoriel de Lutte contre le SIDA (PNMLS). Rapport National de suivi de la declaration d’engagement UNGASS, Kinshasa. 2010.Google Scholar
- 18.HIV infection diagnostic strategy by WHO, National AIDS program (PNLS). 2007.Google Scholar