Abstract
Prenatal exposure of mother to valproic acid causes teratogenic effects on fetus. The authors report an 18 h-old girl with typical facial and limbs features of fetal valproate syndrome (FVS) along with abnormal draining of left superior vena cava into left atrium.
References
Dean JC, Hailey H, Moore SJ, Lloyd DJ, Turnpenny PD, Little J. Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth. J Med Genet. 2002;39:251–9.
Mawer G, Clayton-Smith J, Coyle H, Kini U. Outcome of pregnancy in women attending an outpatient epilepsy clinic: adverse features associated with higher doses of sodium valproate. Seizure. 2002;11:512–8.
Dieterich E, Steveling A, Lukas A, Seyfeddinipur N, Spranger J. Congenital anomalies in children of epileptic mothers and fathers. Neuropediatrics. 1980;11:274–83.
Van Allen MI, Kalousek DK, Chernoff GF, et al. Evidence for multi-site closure of the neural tube in human. Am J Med Genet. 1993;47:723–43.
Kozma C. Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and review of the literature. Am J Med Genet. 2001;98:168–75.
Buirski G, Jordan SC, Joffe HS, Wilde P. Superior vena caval abnormalities: their occurrence rate, associated cardiac abnormalities and angiographic classification in pediatric population with congenital heart disease. Clin Radiol. 1986;37:131–8.
Raghib G, Ruttenberg HD, Anderson RC, Amplatz K, Adams P Jr, Edwards JE. Termination of left superior vena cava in left atrium, septal defect and absence of coronary sinus; a developmental complex. Circulation. 1965;31:906–18.
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Sarkar, S., Sardar, S.K., Munian, D. et al. An Anomalous Left Superior Venacava Draining into Left Atrium in association with Fetal Valproate Syndrome. Indian J Pediatr 80, 604–606 (2013). https://doi.org/10.1007/s12098-012-0811-z
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DOI: https://doi.org/10.1007/s12098-012-0811-z