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Calcified Cerebral Cryptococcal Granuloma

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Abstract

The authors report a 12-mo-old girl with calcified cerebral cryptococcal granuloma. She was admitted with a 6-mo history of seizures. Laboratory examinations showed no abnormal findings. Electroencephalography revealed bilateral slow wave activity, greater in the right occipital region. CT showed an irregular calcified focus with small surrounding low density in the right parieto-occipital region. MRI demonstrated mixed signals without edema and visible flow-voids. The clinical symptoms mimicked intracranial vascular malformations. The diagnosis of cerebral cryptococcal granuloma was made by histopathology. Partial resection of the lesion with post-operatively antifungal and anticonvulsant therapy offered the satisfactory result. Cerebral cryptococcal granuloma is extremely rare, especially in infants. Calcification is indeed unusual. Cerebral cryptococcal granuloma should be included in the differential diagnosis of intracranial mass with calcification in infants.

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Authors and Affiliations

  1. Department of Radiology, East Hospital, Tongji University School of Medicine, Shanghai, China

    Jing-Qi Zhu, Xiao-Feng Tao & Nan-Xin Hao

  2. Department of Pediatrics, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China

    Wei-Qun Bao

  3. Department of Pathology, Xin Hua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

    Xiang-Ru Wu

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  1. Jing-Qi Zhu
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  2. Xiao-Feng Tao
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  3. Wei-Qun Bao
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  4. Nan-Xin Hao
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  5. Xiang-Ru Wu
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Correspondence to Wei-Qun Bao.

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Zhu, JQ., Tao, XF., Bao, WQ. et al. Calcified Cerebral Cryptococcal Granuloma. Indian J Pediatr 80, 345–348 (2013). https://doi.org/10.1007/s12098-012-0758-0

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  • DOI: https://doi.org/10.1007/s12098-012-0758-0

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