Skip to main content
Log in

Role of Interferon Gamma Release Assays in Childhood Tuberculosis

  • Commentary
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. WHO Report. Global tuberculosis control. Geneva: World Health Organization; 2011.

    Google Scholar 

  2. Keeler E, Perkins MD, Small P, et al. Reducing the global burden of tuberculosis: the contribution of improved diagnostics. Nature. 2006;444:49–57.

    Article  PubMed  Google Scholar 

  3. Lalvani A, Millington K. T cell-based diagnosis of childhood tuberculosis infection. Curr Opin Infect Dis. 2007;20:264–71.

    Article  PubMed  Google Scholar 

  4. Pai M, Zwerling A, Menzies D. Systematic review: T-cell based assays for the diagnosis of latent tuberculosis infection—an update. Ann Intern Med. 2008;149:177–84.

    PubMed  Google Scholar 

  5. Machingaidze S, Wiysonge CS, Gonzalez-Angulo Y, et al. The utility of an Interferon-gamma release assay for diagnosis of latent tuberculosis infection and disease in children. A systematic review and meta-analysis. Pediatr Infect Dis J. 2011;30:694–700.

    Article  PubMed  Google Scholar 

  6. WHO. Use of interferon-γ release assays (IGRAs) in TB control in low and middle-income settings. World Health Organisation; 2010.

  7. ECDC. Use of interferon-gamma release assays in support of TB diagnosis. Stockholm: European Centre for Disease Prevention and Control; 2011.

    Google Scholar 

  8. Mandalakas AM, Detjen AK, Hesseling AC, Benedetti A, Menzies D. Interferon gamma release assays and childhood tuberculosis: systematic review and meta-analysis. Int J Tubercul Lung Dis. 2011;15:1018–32.

    Article  CAS  Google Scholar 

  9. Okada K, Mao T, Mori T, et al. Performance of an interferon-gamma release assay for diagnosing latent tuberculosis infection in children. Epidemiol Infect. 2008;136:1179–87.

    Article  PubMed  CAS  Google Scholar 

  10. Kampmann B, Whittaker E, Williams S, et al. Interferon-γ release assays do not identify more children with active tuberculosis than the tuberculin skin test. Eur Respir J. 2009;33:1374–82.

    Article  PubMed  CAS  Google Scholar 

  11. Bramford A, Crook A, Clark J, et al. Comparison of interferon-gamma release assays and tuberculin skin test in predicting active tuberculosis (TB) in children in the UK—a paediatric TB network study. PLoS One. 2009;4:e4130.

    Article  Google Scholar 

  12. Dayal R, Verma V, Sharma B, et al. Diagnostic value of interferon-gamma release assays in childhood tuberculosis. Indian J Pediatr. 2012. doi:10.1007/s12098-011-0469-y

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Soumya Swaminathan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Swaminathan, S. Role of Interferon Gamma Release Assays in Childhood Tuberculosis. Indian J Pediatr 79, 250–252 (2012). https://doi.org/10.1007/s12098-011-0681-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-011-0681-9

Keywords

Navigation