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Bordetella Pertussis IgG and IgA Antibodies Seroprevalence Among 1–35 y-old Population: The Role of Subclinical Pertussis Infection



To determine age-dependent pertussis specific IgG and IgA antibodies seroprevalence in apparently healthy subjects.


A total of 595 healthy 1-35-y-old individuals divided into 5 different age groups were selected from Sari district. Antipertussis IgG and IgA antibodies levels were measured quantitatively by ELISA method. Positive sera for IgA and also IgG titer ≥150 were considered for recent pertussis infection.


High seroprevelence levels (72% and 71%) were observed among preschool (<7 y) children. After decreasing the seroprevelence rates significally to lowest level (54.4%) among school aged (7–11 y), the rates increased again to the highest levels of 60% and 73% at adulthood (P = 0.03 and P = 0.003). In total, 1.55% of study subjects were IgA positive, and 5.7% showed high IgG titers.


The present study reveals, vaccine induced immunity has decreased among school-aged children and natural pertussis infection is common among adolescent and young adults. Also, asymptomatic/sub-clinical recent pertussis infection was prevalent among studied population. These findings necessitate developing new strategies to reduce and control pertussis infection in Iran.

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The authors wish to thanks public health staff for their help in recruiting subjects for this study, and parents of children and children for their participation in this study.

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Role of Funding Source

This work was supported by vice-chancellor for research Mazandaran University of Medical Sciences Grant No 8835, 2008.6.24.

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Correspondence to Mohammed-Jafar Saffar.

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Saffar, MJ., Khalilian, AR., Rafee, AR. et al. Bordetella Pertussis IgG and IgA Antibodies Seroprevalence Among 1–35 y-old Population: The Role of Subclinical Pertussis Infection. Indian J Pediatr 79, 353–357 (2012).

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  • Pertussis
  • Pertussis infection
  • Pertussis IgG seroprevalence
  • Pertussis IgA seroprevalence