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Neonatal Brucellosis and Breast Milk


In this case report the authors present an extremely low birth weight premature infant with neonatal brucellosis whose mother had been treated for brucellosis during pregnancy. Infant developed mild respiratory distress syndrome soon after birth. At 2nd wk of postnatal age findings of bronchopulmonary dysplasia were evident and she and her mother were diagnosed to have brucellosis at the same time. After commencement of antibrucellosis therapy and nonspesific treatment for bronchopulmonary dysplasia, infant was completely cured of the symptoms related to both brucellosis and bronchopulmonary dysplasia. The results of the present case and a review of the literature have let to conclude that Brucella might have role in development of prematurity and bronchoplumonary dysplasia. Since discovery of brucella bacilli in early periods of 20th century, fetotoxicity of brucella bacilli seems to increase gradually suggesting an increasing virulance of the bacilli or vanishing host defense of human beings.

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  1. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006;6:91–9.

    PubMed  Article  Google Scholar 

  2. Kurdoglu M, Adali E, Kurdoglu Z, Karahocagil MK, Kolusari A, Yildizhan R, et al. Brucellosis in pregnancy: a 6-year clinical analysis. Arch Gynecol Obstet. 2010;281:201–6.

    PubMed  Article  Google Scholar 

  3. Koklu E, Buyukkayhan D, Akcakus M, Kurtoglu S, Koklu S, Gunes T. Brucellosis with pulmonary involvement in a premature infant. Ann Trop Paediatr. 2006;26:367–70.

    PubMed  Article  Google Scholar 

  4. Chheda S, Lopez SM, Sanderson EP. Congenital brucellosis in a premature infant. Pediatr Infect Dis J. 1997;16:81–3.

    PubMed  Article  CAS  Google Scholar 

  5. Carpenter CM, Boak R. Brucella Abortus in Milk and Dairy Products. Am J Public Health Nations Health. 1928;18:743–51.

    PubMed  Article  CAS  Google Scholar 

  6. Poele PM, Whitehouse DB, Gilchrist MM. A case of abortion consequent upon infection with Brucella abortus biotype 2. J Clin Pathol. 1972;25:882–4.

    Article  Google Scholar 

  7. Young EJ. Human brucellosis. Rev Infect Dis. 1983;5:821–42.

    PubMed  Article  CAS  Google Scholar 

  8. Elshamy M, Ahmed AI. The effects of maternal brucellosis on pregnancy outcome. J Infect Dev Ctries. 2008;2:230–4.

    PubMed  Article  Google Scholar 

  9. Williamson AR. Abortion in Brucella abortus Fever. Br Med J. 1944;1:752.

    PubMed  Article  CAS  Google Scholar 

  10. Gloeb DJ, Lupi C, O’Sullivan MJ. Neurobrucellosis complicating pregnancy: a case report. Infect Dis Obstet Gynecol. 1994;1:285–9.

    PubMed  Article  CAS  Google Scholar 

  11. Khan MY, Mah MW, Memish ZA. Brucellosis in pregnant women. Clin Infect Dis. 2001;32:1172–7.

    PubMed  Article  CAS  Google Scholar 

  12. Sayılır K, Sayın Kutlu S, Baykam N, et al. Spontaneous abortion due to brucellosis: Report of two cases. Turk J Infect. 2003;17:345–8.

    Google Scholar 

  13. Mosayebi Z, Movahedian AH, Ghayomi A, Kazemi B. Congenital brucellosis in a preterm neonate. Indian Pediatr. 2005;42:599–601.

    PubMed  Google Scholar 

  14. Arroyo Carrera I, López Rodríguez MJ, Sapiña AM, López Lafuente A, Sacristán AR. Probable transmission of brucellosis by breast milk. J Trop Pediatr. 2006;52:380–1.

    PubMed  Article  Google Scholar 

  15. Imani R, Shamsipoor E, Khadivi R. Congenital brucellosis in an infant. Iran J Clin Infect Dis. 2007;2:29–31.

    Google Scholar 

  16. Çetin N, Akduman İ, Kaya A, Helvacı M, İnce Bağ Ö. A case of neonatal brucellosis. Tepecik Eğit Hast Derg. 2009;19:46–8.

    Google Scholar 

  17. Karcaaltincaba D, Sencan I, Kandemir O, Guvendag-Guven ES, Yalvac S. Does brucellosis in human pregnancy increase abortion risk? Presentation of two cases and review of literature. J Obstet Gynaecol Res. 2010;36:418–23.

    PubMed  Article  Google Scholar 

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Correspondence to Murat Köstü.

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Ceylan, A., Köstü, M., Tuncer, O. et al. Neonatal Brucellosis and Breast Milk. Indian J Pediatr 79, 389–391 (2012).

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  • Brucellosis
  • Transmission
  • Breast milk
  • Neonatal