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Acute Myeloid Leukemia (AML-M2) with Translocation (8;21) (q22;q22) and Abnormal Eosinophilic Precursors in the Bone Marrow—A Case Report

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Abstract

The translocation (8;21)(q22;q22) is frequently associated with M2 subtype of AML. The authors herein present a case of AML-M2 in a nine-year-old boy without hepatosplenomegaly, lymphadenopathy or any bleeding diathesis. Bone marrow examination revealed high number of eosinophilic precursors (60%) among the total nucleated bone marrow cells. Cytogenetic study with G- banding method showed 46, XY, t (8;21)(q22;q22). The morphological abnormalities in eosinophils observed in AML suggested that eosinophils may be a part of leukemic process.

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Authors and Affiliations

  1. Department of Pathology, VMMC and Safdarjung Hospital, New Delhi, India

    Oneal Gupta, Roopak Aggarwal & Rajni Prasad

  2. Sector III-A, H.NO.26, Ground Floor, Rachna Vaishali, Ghaziabad, 201010, India

    Oneal Gupta

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  1. Oneal Gupta
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  2. Roopak Aggarwal
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  3. Rajni Prasad
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Correspondence to Oneal Gupta.

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Gupta, O., Aggarwal, R. & Prasad, R. Acute Myeloid Leukemia (AML-M2) with Translocation (8;21) (q22;q22) and Abnormal Eosinophilic Precursors in the Bone Marrow—A Case Report. Indian J Pediatr 79, 256–259 (2012). https://doi.org/10.1007/s12098-011-0481-2

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  • DOI: https://doi.org/10.1007/s12098-011-0481-2

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