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Effect of Pseudoephedrine on Cardiac Rhythm of Children with Rhinitis

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Abstract

Objective

To investigate the effect of pseudoephedrine on heart rhythm of children with rhinitis.

Methods

The study included 25 children diagnosed with rhinitis from March 2009 through February 2010 in the Department of Pediatrics. Holter records were obtained for 24 h before and at the fourth day of pseudoephedrine treatments.

Results

Study group consisted of 18 girls (72%) and 7 boys (28%) with a mean age of 8.7 ± 3.4 (4–17.9 years). Common complaints of the patients were rhinorrhea (100%), cough (68%) fatigue (48%), sore throat (36%), and headache (28%). Of the 25 patients whose Holter recordings were evaluated, rare supraventricular extrasystoles were observed in one prior to the administration of pseudoephedrine, which were not repeated on this patient’s follow-up recording on day four. There were two ventricular extrasystoles in the day four Holter recording of another patient. None of the patients complained of chest pain or palpitation. There were no observations of supraventricular tachycardia, ventricular tachycardia or ventricular fibrillation. No statistical differences could be found (p > 0.05) in the values before treatment and those on day four of treatment of either the time-dependent Heart rate variability (HRV) parameters SDNN, SDNN index, SDANN and RMSSD, or the frequency-dependent parameters (TP, HF, LF). No statistical difference could be determined between heart rate values of the patients before treatment and those on day four of treatment (p > 0.05).

Conclusions

This study has established that therapeutic doses of pseudoephedrine do not cause an additional dysrhythmia risk for children with no health problem except rhinitis.

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Conflict of Interest

None.

Role of Funding Source

This study was supported by the Scientific Research Fund of Fatih University.

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Faculty of Medicine, Fatih University, Alparslan Turkes Caddesi No: 57, 06510, Ankara, Turkey

    Meki Bilici & Sadi Turkay

  2. Department of Pediatrics, Faculty of Medicine, Fatih University, Ankara, Turkey

    Ayse Esra Yılmaz, Ferhat Catal & Alparslan Tonbul

  3. Department of Ear, Nose and Throat, Faculty of Medicine, Fatih University, Ankara, Turkey

    Hanifi Kurtaran

  4. Department of Cardiology, Faculty of Medicine, Fatih University, Ankara, Turkey

    Yusuf Selcoki

  5. Department of Pediatric Cardiology, Dr. Sami Ulus Children Hospital, Ankara, Turkey

    Utku Arman Orun

Authors
  1. Meki Bilici
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  2. Sadi Turkay
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  3. Ayse Esra Yılmaz
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  4. Hanifi Kurtaran
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  5. Ferhat Catal
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  6. Alparslan Tonbul
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  7. Yusuf Selcoki
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  8. Utku Arman Orun
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Correspondence to Meki Bilici.

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Bilici, M., Turkay, S., Yılmaz, A.E. et al. Effect of Pseudoephedrine on Cardiac Rhythm of Children with Rhinitis. Indian J Pediatr 78, 1361–1364 (2011). https://doi.org/10.1007/s12098-011-0476-z

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  • DOI: https://doi.org/10.1007/s12098-011-0476-z

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