Skip to main content

Advertisement

Log in

Necrotizing Enterocolitis in a Term Neonate Following Intravenous Immunoglobulin Therapy

  • Clinical Brief
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

A term baby with severe BO isoimmunization was treated with intravenous immunoglobulin. Shortly after the completion of the infusion, the baby developed clinical and radiological signs of necrotizing enterocolitis, with intestinal perforation and massive hemorrhagic ascites, resulting in the death of the baby.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Derycke M, Dreyfus M, Ropert JC, Tchernia G. Intravenous immunoglobulin for neonatal isoimmune thrombocytopenia. Arch Dis Child. 1985;60:667–9.

    Article  PubMed  CAS  Google Scholar 

  2. Gottstein R, Cooke RWI. Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn. Arch Dis Child Fetal Neonatal Ed. 2003;88:F6–10.

    Article  PubMed  CAS  Google Scholar 

  3. Maayan-Metzger A, Itzchak A, Mazkereth R, Kuint J. Necrotizing enterocolitis in full-term infants: case-control study and review of the literature. J Perinatol. 2004;24:494–9.

    Article  PubMed  Google Scholar 

  4. Rübo J, Albrecht K, Lasch P, et al. High-dose intravenous immune globulin therapy for hyperbilirubinemia caused by Rh hemolytic disease. J Pediatr. 1992;121:93–7.

    Article  PubMed  Google Scholar 

  5. Merlob P, Litmanovitch I, Mor N, Litwin A, Wielunsky E. Necrotizing enterocolitis after intravenous immunoglobulin treatment for neonatal isoimmune thrombocytopenia. Eur J Pediatr. 1990;149:432–3.

    Article  PubMed  CAS  Google Scholar 

  6. Navarro M, Negre S, Matoses ML, Golombek SG, Vento M. Necrotizing enterocolitis following the use of intravenous immunoglobulin for haemolytic disease of the newborn. Acta Paediatr. 2009;98:1214–7.

    Article  PubMed  Google Scholar 

  7. Katz U, Achiron A, Sherer Y, Shoenfeld Y. Safety of intravenous immunoglobulin (IVIG) therapy. Autoimmun Rev. 2007;6:257–9.

    Article  PubMed  CAS  Google Scholar 

  8. Roig JC, Burchfield DJ. Term neonates with hemolytic disease of the newborn and necrotizing enterocolitis: a report of two cases. J Perinatol. 1994;14:201–3.

    PubMed  CAS  Google Scholar 

  9. Dalakas MC. High-dose intravenous immunoglobulin and serum viscosity: risk of precipitating thromboembolic events. Neurology. 1994;44:223–6.

    PubMed  CAS  Google Scholar 

  10. Bagci S, Eis-Hübinger AM, Yassin AF, et al. Clinical characteristics of viral intestinal infection in preterm and term neonates. Eur J Clin Microbiol Infect Dis. 2010;29:1079–84.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of Interest

None.

Role of Funding Source

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lalitha Krishnan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Krishnan, L., Pathare, A. Necrotizing Enterocolitis in a Term Neonate Following Intravenous Immunoglobulin Therapy. Indian J Pediatr 78, 743–744 (2011). https://doi.org/10.1007/s12098-010-0334-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-010-0334-4

Keywords

Navigation