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Are Interleukin-6, Body Mass Index and Atopy Crucial in Infantile Intussusception?

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Abstract

Objective

To determine the role of inflammation related to body mass index (BMI) and atopy in the etiology of idiopathic intussusception (IS) which is seen more frequently in obese children and which is considered to increase in the allergy season.

Methods

The study comprised a study group consisting of 22 infants with IS and a control group consisting of 20 healthy infants with age and BMI matched. In both groups, gender, weight, height, month of birth, month of admittance (allergy season) of each infant were recorded. Information regarding whether or not the child had any skin rash, atopy, oral allergy syndrome, and whether or not the patient had been fed cow’s milk and breast milk was recorded. Hemoglobin (Hb) levels, white blood cell (WBC) and eosinophil counts, interleukin-6 (IL-6) levels and allergy panel were studied in all patients. Additionally, cross reactive protein (CRP) and blood urea nitrogen (BUN) levels were determined in the study group. During statistical comparison p < 0.05 was considered statistically significant.

Results

Mean IL-6 levels in the control and study groups were 1.59 ± 0.15 pg/ml and 4.12 ± 5.04 pg/ml, respectively. IL-6 levels were statistically different between each groups and between cases with barium reduction and cases reduced manually by laparotomy within the study group. Both groups were similar statistically with regard to the others parameters. No atopy was detected by allergy panel. When binary logistic regression analysis with the cut-off value of IL-6 set as 1.6 pg/ml was applied to all data, statistically significant values were obtained only when the case was in the study group and when CRP levels were increased (p = 0.05 and p = 0.001, respectively).

Conclusions

We demonstrated that IL-6 levels are increased in the study group, especially in the operated patients, however, that high BMI and atopy have no effects on this fact and that atopy is not associated with IS in the clinical study.

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References

  1. Fischer TK, Bihrmann K, Perch M, Koch A, Wohlfahrt J, Kare M, et al. Intussusception in early childhood: a cohort study of 1.7 million children. Pediatrics. 2004;114(3):782–5.

    Article  PubMed  Google Scholar 

  2. Stringer MD, Pablot SM, Brereton RJ. Paediatric intussusception. Br J Surg. 1992;79(9):867–76.

    Article  CAS  PubMed  Google Scholar 

  3. Mayell MJ. Intussusception in infancy and childhood in Southern Africa. A review of 223 cases. Arch Dis Child. 1972;47(251):20–5.

    Article  CAS  PubMed  Google Scholar 

  4. Stevenson RJ. Non-neonatal intestinal obstruction in children. Surg Clin North Am. 1975;65(5):1217–34.

    Google Scholar 

  5. Ein SH, Daneman A. Intussusception. In: Grosfeld JL, O’Neill Jr JA, Fonkalsrud EW, Coran AG, editors. Pediatric surgery. 6th ed. Philadelphia: Mosby; 2006. p. 1313–37.

    Google Scholar 

  6. Bruce J, Huh YS, Cooney DR, Karp MP, Allen JE, Jewett Jr TC. Intussusception: evolution of current management. J Pediatr Gastroenterol Nutr. 1987;6(5):663–74.

    Article  CAS  PubMed  Google Scholar 

  7. Guo JZ, Ma XY, Zhou QH. Results of air pressure enema reduction of intussusception: 6, 396 cases in 13 years. J Pediatr Surg. 1986;21(12):1201–3.

    Article  CAS  PubMed  Google Scholar 

  8. Kim YS, Rhu JH. Intussusception in infancy and childhood. Analysis of 385 cases. Int Surg. 1989;74(2):114–8.

    CAS  PubMed  Google Scholar 

  9. Ong NT, Beasley SW. The leadpoint in intussusception. J Pediatr Surg. 1990;25(6):640–3.

    Article  CAS  PubMed  Google Scholar 

  10. Pang LC. Intussusception revisited: clinicopathologic analysis of 261 cases, with emphasis on pathogenesis. South Med J. 1989;82(2):215–28.

    CAS  PubMed  Google Scholar 

  11. Turner D, Rickwood AM, Brereton RJ. Intussusception in older children. Arch Dis Child. 1980;55(7):544–6.

    Article  CAS  PubMed  Google Scholar 

  12. Ravitch MM. Intussusception. In: Welch KJ, Randolph JG, Ravitch MM, O’Neill JA, Rowe MI, editors. Pediatric surgery. Chicago: Year Book Medical Publishers, Inc; 1986. p. 868–82.

    Google Scholar 

  13. Chiellini C, Bertacca A, Novelli SE, Görgün CZ, Ciccarone A, Giordano A, et al. Obesity modulates the expression of haptoglobin in the white adipose tissue via TNF alpha. J Cell Physiol. 2002;190(2):251–8.

    Article  CAS  PubMed  Google Scholar 

  14. do Nascimento CO, Hunter L, Trayhurn P. Regulation of haptoglobin gene expression in 3 T3-L1 adipocytes by cytokines, catecholamines, and PPAR gamma. Biochem Biophys Res Commun. 2004;313(3):702–8.

    Article  PubMed  Google Scholar 

  15. Pérez-Echarri N, Pérez-Matute P, Marcos-Gómez B, Baena MJ, Marti A, Martínez JA, et al. Differential inflammatory status in rats susceptible or resistant to diet-induced obesity: effects of EPA ethyl ester treatment. Eur J Nutr. 2008;47(7):380–6.

    Article  PubMed  Google Scholar 

  16. Cavaillon JM. Contribution of cytokines to inflammatory mechanisms. Pathol Biol (Paris). 1993;41:799–811.

    CAS  PubMed  Google Scholar 

  17. Neyzi O, Gunoz H, Furman A, Bundak R, Gokcay G, Darendeliler F, et al. Weight, Height, head circumfrence and body mass index references for Turkish children. Çocuk Sağlığı ve Hastalıkları Dergisi. 2008;51:1–14.

    Google Scholar 

  18. Waseem M, Rosenberg HK. Intussusception. Pediatr Emerg Care. 2008;24(11):793–800.

    Article  PubMed  Google Scholar 

  19. Ekiz C, Agaoglu L, Karakas Z, Gurel N, Yalcin I. The effect of iron deficiency anemia on the function of the immune system. Hematol J. 2005;5(7):579–83.

    Article  CAS  PubMed  Google Scholar 

  20. Pisacane A, Caracciolo G, de Luca U, Grillo G, Simeone C, Impagliazzo N, et al. Infant feeding and idiopathic intussusception. J Pediatr. 1993;123(4):593–5.

    Article  CAS  PubMed  Google Scholar 

  21. Jayasooriya S, Fox AT, Murch SH. Do not laparotomize food-protein-induced enterocolitis syndrome. Pediatr Emerg Care. 2007;23(3):173–5.

    Article  PubMed  Google Scholar 

  22. Miyoshi M, Nagata K, Imoto T, Goto O, Ishida A, Watanabe T. ANG II is involved in the LPS-induced production of proinflammatory cytokines in dehydrated rats. Am J Physiol Regul Integr Comp Physiol. 2003;284:R1092–7.

    CAS  PubMed  Google Scholar 

  23. Willetts IE, Kite P, Barclay GR, Banks RE, Rumley A, Allgar V, et al. Endotoxin, cytokines and lipid peroxides in children with intussusception. Br J Surg. 2001;88(6):878–83.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Bilge Karabulut.

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Karabulut, B., Erdoğan, D., Bostancı, İ. et al. Are Interleukin-6, Body Mass Index and Atopy Crucial in Infantile Intussusception?. Indian J Pediatr 77, 1257–1260 (2010). https://doi.org/10.1007/s12098-010-0218-7

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  • DOI: https://doi.org/10.1007/s12098-010-0218-7

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