Abstract
Objective
To delineate the clinical behavior of SLE in children from Eastern India and to the differences in disease pattern.
Methods
In the present study, all 44 patients of pediatric SLE who were diagnosed over a period of 5 years in our pediatric rheumatology clinic were followed prospectively. The resultant database was analyzed using standard statistical methods.
Results|About 3.9% of all rheumatology cases dealt with in the clinic in the last five yrs (n=1063) were SLE. The number of children in 5–8 yrs and 8–12 yrs age groups were 13 and 27, respectively. The overall female (n=35) to male (n=9) ratio in this study was 3.8:1. Renal, hematological and Neuropsychiatric features were most common major organ manifestations(54%,54% and 25% respectively). Joints and skin were the most common minor organs involved. Two case were ANA negative SLE. Among the typical features of ANA negative disease, only nephritis was found in these patients. Anti dsDNA was positive in 50 % cases (n=21). C3 levels were studied in all cases with nephritis (n=22) and 68 % (n=15) had hypocomplementemia. Anti Ro and anti La antibodies were positive in two cases of neonatal lupus. APLA, Anti Sm antibody and anti U1RNP were negative in the cases where testing was done
Conclusions
This study has tried to delineate the disease trends of childhood lupus from Eastern India. Certain important trends have emerged which are different from other contemporary Indian and International observations.
Similar content being viewed by others
References
Al Salloum AA. Lupus nephritis in childhood. Saudi J Kidney Dis Transpl 2003; 14: 43–56.
Cassidy JT, Petty RE. Systemic Lupus Erythematosus. In editors name? Textbook of Pediatric Rheumatology, 4th ed., Philadelphia; W.B. Saunders Company, 2001; 396–449.
Brunner HI, Gladman DD, Ibañez D et al. Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum 2008; 58: 556–562.
Ali US, Dalvi RB, Merchant RH et al. Systemic lupus erythematosus in Indian children. Indian Pediatr 1989; 26: 868–873.
Chandrasekaran AN, Rajendran CP, Ramakrishnan S, Madhavan R, Parthiban M. Childhood systemic lupus erythematosus in south India. Indian J Pediatr 1994; 61: 223–229.
Singh S, Kumar L, Khetarpal R et al. Clinical and immunological profile of SLE: some unusal features. Indian Pediatr 1997; 34: 979–986.
Agarwal I, Kumar T S, Ranniji K, Kirubakaran C, Danda D. Clinical features and Outcome of Systemic Lupus Erythematosus. Indian Pediatr 2009; 46: 711–715.
Pande I, Sekharan NG, Kailash S et al. Analysis of clinical laboratory profile in Indian childhood systemic lupus erythematosus and its comparison with SLE in adults. Lupus 1993; 2: 83.
Benseler SM, Silverman ED. Neuropsychiatric involvement in pediatric systemic lupus erythematosus. Lupus 2007; 16: 564–571.
Singh S, Gupta MK, Ahluwalia J et al. Neuropsychiatric manifestations and antiphospholipid antibodies in pediatric onset lupus: 14 years of experience from a tertiary center of North India. Rheumatol Int 2009; 29: 1455–1461. Epub 2009 Mar 22.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mondal, R., Nandi, M., Ganguli, S. et al. Childhood lupus: Experience from Eastern India. Indian J Pediatr 77, 889–891 (2010). https://doi.org/10.1007/s12098-010-0126-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-010-0126-x