Skip to main content

Advertisement

Log in

Osseous involvement in pediatric Hodgkin’s lymphoma

  • Clinical Brief
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Presented here is a report of 3 children, out of 66 total pediatric Hodgkin’s lymphoma (HL) patients (4.5%) with bone involvement over a 3 and a half year period. Two patients presented with osseous lesions at the time of relapse and one had concurrent evidence of non-osseous disease. The clinical presentation, radiographic findings, histology, treatment and outcome of these patients are discussed. Boys and girls are nearly equally affected, local bone pain is the commonest symptom and B-symptoms are common. Vertebrae and pelvis are most frequently involved, commonly with an osteolytic picture. Nodular sclerosis is the predominant histological subtype. Most children received combined modality treatment and the overall response and survival are good.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Newcomer LN, Silverstein MB, Cadman EC, Farber LR, Bertino JR, Prosnitz LR. Bone involvement in Hodgkin’s disease. Cancer 1982;49:338–342

    Article  CAS  PubMed  Google Scholar 

  2. Ostrowski ML, Unni KK, Banks PM, Shives TC, Evans RG, O’Connell MJ et al. Malignant lymphoma of bone. Cancer 1986; 58: 2646–2655.

    Article  CAS  PubMed  Google Scholar 

  3. Ostrowski ML, Inwards CY, Strickler JG, Witziq TE, Wenger DE, Unni KK. Osseous Hodgkin’s disease. Cancer 1999; 5: 1166–1178.

    Article  Google Scholar 

  4. Gross SB, Robertson WW Jr., Lange BJ, Bunin NJ, Drummond DS. Primary Hodgkin’s disease of bone: a report of two cases in adolescents and review of the literature. Clin Orthop 1992; 283: 276–280.

    PubMed  Google Scholar 

  5. Chan K-W, Rosen G, Miller DR, Tan CTC. Hodgkin’s disease in adolescents presenting as a primary bone lesion: a report of four cases and review of the literature. Am J Pediatr Hematol Oncol 1982;4: 11–17.

    CAS  PubMed  Google Scholar 

  6. Köseoglu RD, Senayli A, Biçakçi U, Onuk-Filiz N, Sezer T, Celkan T. Osseous presentation of Hodgkin’s disease: a case report and review of the literature. Turk J Pediatr 2007;49: 218–222.

    PubMed  Google Scholar 

  7. Mandell GA. Resolution of Hodgkin’s induced ivory vertebrae. Pediatr Radiol 1978; 7: 178–179.

    Article  CAS  PubMed  Google Scholar 

  8. Appell RG, Oppermann HC, Brandeis WE. Skeletal lesions in Hodgkin’s disease. Review of literature and case reports. Pediatr Radiol 1981;11: 61–65.

    Article  CAS  PubMed  Google Scholar 

  9. Sullivan WT, Solonick DM. Case report 414: nodular sclerosing Hodgkin disease involving sternum and chest wall. Skeletal Radiol 1987;16:166–169.

    Article  CAS  PubMed  Google Scholar 

  10. Ozdemirli M, Mankin HJ, Aisenberg AC, Harris NL. Hodgkin’s disease presenting as a solitary bone tumor. Cancer 1996;77:79–88.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sameer Bakhshi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Singh, P., Bakhshi, S. Osseous involvement in pediatric Hodgkin’s lymphoma. Indian J Pediatr 77, 565–566 (2010). https://doi.org/10.1007/s12098-010-0019-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-010-0019-z

Key words

Navigation