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Obesity and thyrotropinemia

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Abstract

Objective

To study the relation between body mass index (BMI) and TSH in euthyroid and subclinical hypothyroid obese children and compared serum TSH level among obese and overweight children.

Methods

Fifty consecutive children (aged 2–18 yr) presenting for obesity were studied. All cases with TSH > 10, low T3/T4, organic and syndromic obesity were excluded. Patients were divided into Group 1: Overweight (n=20) (BMI between 85th to 95th centile) and Group 2: Obesity (n=30) (BMI > 95th centile). Fisher’s exact test, Mann-Whitney U test and Pearson’s correlation were used for statistical analysis. P value < 0.05 was considered significant.

Results

Elevated TSH level (between 4.5–10 mIU/L) with normal T3, T4 was seen in 4/20 overweight and 9/30 of obese children (P=0.5219). The mean TSH was comparable in both the groups (3.22 ± 3.1 mIU/L vs. 3.63 ± 2.2 mIU/L, P=0.3491). Overall TSH showed no correlation with BMI (r= 0.0014, P=0.9924).

Conclusion

The preliminary data did not show any relation between severity of obesity and TSH level. Further large scale data from population are required to confirm these findings.

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References

  1. Agarwal RK. Childhood Obesity: Emerging Challenge. Indian Pediatr 2008; 45: 443–444.

    Article  CAS  PubMed  Google Scholar 

  2. Marwaha RK, Tandon N, Singh Y, Aggarwal R, Grewal K, Mani K. A study of growth parameters and prevalence of overweight and obesity in school children from Delhi. Indian Pediatr 2006; 43: 943–952.

    PubMed  Google Scholar 

  3. Mehta M, Bhasin SK, Agrawal K, Dwivedi S. Obesity amongst affluent adolescent Girls. Indian J Pediatr 2007; 74: 619–622.

    Article  CAS  PubMed  Google Scholar 

  4. Kelishadi R. Childhood Obesity: Today’s and Tomorrow’s Health Challenge. Indian Pediatr 2008; 45: 451–452.

    PubMed  Google Scholar 

  5. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008;29:76–131.

    Article  CAS  PubMed  Google Scholar 

  6. Eliakim A, Barzilai M, Wolach B, Nemet D. Should we treat elevated thyroid stimulating hormone levels in obese children and adolescents? Int J Pediatr Obes 2006;1:217–221.

    Article  PubMed  Google Scholar 

  7. Wolf M, Weigert A, Kreymann G. Body composition and energy expenditure in thyroidectomized patients during short term hypothyroidism and thyrotropin-suppressive thyroxine therapy. Eur J Endocrinol 1996; 134: 168–173.

    Article  CAS  PubMed  Google Scholar 

  8. Michalaki MA, Vagenakis AG, Leonardou AS, Argentou MN, Habeos IG, Makri MG et al. Thyroid function in humans with morbid obesity. Thyroid 2006; 16:73–78.

    Article  CAS  PubMed  Google Scholar 

  9. Reinehr T, de Sousa G, Andler W. Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J Clin Endocrinol Metab 2006;91:3088–3091.

    Article  CAS  PubMed  Google Scholar 

  10. Reinehr T, Andler W. Thyroid hormones before and after weight loss in obesity. Arch Dis Child 2002;87:320–323.

    Article  CAS  PubMed  Google Scholar 

  11. Nyrnes A, Jorde R, Sundsfjord J. Serum TSH is positively associated with BMI. Int J Obes (Lond) 2006; 30: 100–105.

    Article  CAS  Google Scholar 

  12. Khadilkar VV, Khadilkar AV, Choudhury P, Agarwal KN, Ugra D, Shah NK. IAP growth monitoring guidelines for children from birth to 18 years. Indian Pediatr 2007;44:187–197.

    CAS  PubMed  Google Scholar 

  13. Bhowmick SK, Dasari G, Levens KL, Rettig KR. The prevalence of elevated serum thyroid-stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Natl Med Assoc 2007;99:773–776.

    PubMed  Google Scholar 

  14. Stichel H, l’Allemand D, Grüters A. Thyroid function and obesity in children and adolescents. Horm Res 2000; 54:14–19.

    Article  CAS  PubMed  Google Scholar 

  15. Mehta S, Mathur D, Chaturvedi M, Devpura G, Jat VS. Thyroid hormone profile in obese subjects—a clinical study. J Ind Med Ass 2001; 99:260–261.

    CAS  Google Scholar 

  16. Feldt-Rasmussen U. Thyroid and leptin. Thyroid 2007; 17:413–419.

    Article  CAS  PubMed  Google Scholar 

  17. Pinkney JH, Goodrick SJ, Katz J et al. Leptin and the pituitarythyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects. Clin Endocrinol (Oxf) 1998;49: 583–588.

    Article  CAS  Google Scholar 

  18. Reinehr T, Hinney A, de Sousa G, Austrup F, Hebebrand J, Andler W. Definable somatic disorders in overweight children and adolescents. J Pediatr 2007; 150: 618–622, 622.e1–5.

    Article  PubMed  Google Scholar 

  19. Marwaha RK, Tandon N, Desai A et al. Reference range of thyroid hormones in normal Indian school-age children. Clin Endocrinol (Oxf) 2008; 68:369–374.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Endocrinology, MEDWIN Hospitals, Hyderabad, AP, India

    K. V. S. Hari Kumar, A. Verma, J. Muthukrishnan & K. D. Modi

  2. Department of Endocrinology, Medwin Hospitals, Nampally, Hyderabad, AP, 500001, India

    K. V. S. Hari Kumar

Authors
  1. K. V. S. Hari Kumar
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  2. A. Verma
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  3. J. Muthukrishnan
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  4. K. D. Modi
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Correspondence to K. V. S. Hari Kumar.

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Hari Kumar, K.V.S., Verma, A., Muthukrishnan, J. et al. Obesity and thyrotropinemia. Indian J Pediatr 76, 933–935 (2009). https://doi.org/10.1007/s12098-009-0153-7

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  • DOI: https://doi.org/10.1007/s12098-009-0153-7

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