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Movement disorders in children: Recent advances in management

  • Symposium on Neurological Disorder-Advances in Management-II
  • Published:
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Abstract

In recent years there has been a growing interest towards pediatric movement disorders (PMD). The data derived from the synthesis of clinical observation, neuroimaging, biochemical and, molecular genetics studies have allowed for the identification of a significant number of pediatric diseases featuring movement disorders. The purpose of this review is to outline an approach to the advances in management of dystonia, neurotransmitter disorders, tics, and paroxysmal dyskinetic syndromes starting in children younger than 18 yr of age.

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References

  1. Fernández-Alvarez E, Aicardi J. Movement disorders in children. London; MacKeith Press, 2001.

    Google Scholar 

  2. Fernández-Alvarez E Transient movements disorders in children. J Neurol 1998; 245: 1–5

    Article  PubMed  Google Scholar 

  3. Moharir MD, Ouvrier RA, Grattan-Smith P Transient movement disorders of infancy and childhood In Fernández-Alvarez E, Arzimanogolou A, Tolosa E, eds. Paediatric movement disorders. Paris; John Libbey Eurotext, 2005.

    Google Scholar 

  4. Dooley JM, Furey S, Gordon KE, Wood EP. Fever-induced dystonia. Pediatric Neurol 2003; 58: 149–150.

    Article  Google Scholar 

  5. Sanger TD. Toward a definition of childhood dystonia. Curr Opin Pediatr 2004; 16: 623–627.

    Article  PubMed  Google Scholar 

  6. Camargos S, Scholtz S, Simón-Sanchez J, Paisán-Ruiz C, Lewis P et al DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA. Lancet Neurol 2008; 7: 215–222

    Article  Google Scholar 

  7. Nardocci N, Zorzi G, Barzaghi C, Zibordi F, Ciano C et al Myoclonus-dystonia syndrome: clinical presentation, disease course, and genetic features in 11 families. Mov Disord 2008; 23: 28–34.

    Article  PubMed  Google Scholar 

  8. Blau N, Thöny B, Cotton RGH, Hyland K. Disorders of tetrahydrobiopterin and related biogenic amines. In Scriver CR, Beaudet AL, Sly Ws et al. eds. The metabolic and molecular bases of inhereted disease, 8th ed. New York: McGraw-Hill, 2001; 1725–1776.

    Google Scholar 

  9. Nardocci N, Zorzi G, Blau N, Fernandez-Alvarez E, Sesta M, Angelini L et al. Neonatal dopa-responsive extrapyramidal syndrome in twins with recessive GTPCH deficiency. Neurology 2003; 60: 335–337.

    PubMed  CAS  Google Scholar 

  10. Grattan-Smith PJ, Wevers RA, Steenbergen-Spanjers GC, Fung VSC, Earl J, Wilcken B. Tyrosine hydroxylase deficiency: clinical manifestations of catecholamine insufficiency in infancy. Mov Disord 2002; 17: 354–359.

    Article  PubMed  Google Scholar 

  11. Breedveld G, van Dongen J, Danesino C, Guala A, Percy AK et al Mutations in TITF-! gene are associated with benign hereditary chorea. Hum Molec Genet 2002; 11: 971–978.

    Article  PubMed  CAS  Google Scholar 

  12. Asmus F, Horber V, Pohlenz J, Schwabe D, Zimprich A et al A novel TITF-1 mutation causes benign hereditary chorea with response to levodopa. Neurology 2005; 64: 1952–1954.

    Article  PubMed  CAS  Google Scholar 

  13. Szepetowski P, Rochette J, Berquin P, Piussan C, Lathrop GM, Monaco AP Familial infantile convulsions and paroxysmal choreoathetosis: a new neurological syndrome linked to the pericentromeric region of human chromosome 16. Am J Hum Genet 1997; 61: 889–898.

    Article  PubMed  CAS  Google Scholar 

  14. Guerrini R, Bonanni P, Nardocci N, Parmeggiani L, Piccirilli M et al. Autosomal recessive rolandic epilepsy with paroxysmal exercise-induced dystonia and writer’s cramp: delineation of the syndrome and gene mapping to chromosome 16p12-11.2. Ann Neurol 1999; 45: 344–352.

    Article  PubMed  CAS  Google Scholar 

  15. Koch C, Bednarek N, Motta J Benign epileptic seizures in infancy followed by paroxysmal choreo-athetosis during adolescence. Epileptic Disord 1999; 2: 141–142.

    Google Scholar 

  16. Swoboda KJ, Soong BW, McKenna C et al. Paroxysmal kinesigenic dyskinesia and infantile convulsions. Clinical and linkage studies. Neurology 2000; 55: 224–230.

    PubMed  CAS  Google Scholar 

  17. Guerrini R, Sanchez-Carpintero R, Deonna T, Santucci M, Bhatia K et al. Early-onset absence epilepsy and paroxysmal dyskinesia. Epilpesia 2002; 43: 1224–1229.

    Article  Google Scholar 

  18. Auburger G, Ratlaff T, Lukes A, Nelles HW, Leube B et al. A gene for autosomal dominant paroxysmal choreoathetosis/spasticity (CSE) maps to the vicinity of a potassium channel gene cluster on chromosome 1p, probably within 2 cM between D1S443 and D1S197. Genomics 1996; 31: 90–94.

    Article  PubMed  CAS  Google Scholar 

  19. Suls A, Dedeken P, Goffin K, Van Esch H, Dupont P et al. Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2AI, encoding the glucose transporter GLUTI. Brain 2008; 131:1831–1844.

    Article  PubMed  Google Scholar 

  20. Fernández-Alvarez E. Prevalence of paediatric movement disorders In Fernández-Alvarez E, Arzimanogolou A, Tolosa E, eds. Paediatric movement disorders. Paris; John Libbey Eurotext, 2005; 1–18.

    Google Scholar 

  21. Singer HS. Tourette’s syndrome: from behaviour to biology Lancet Neurol 2005; 4: 149–159.

    PubMed  Google Scholar 

  22. Burd L, Kerbershian J. Onset of Gilles de la Tourette’s syndrome before 1 year of age. Am J Psychiatry 1987; 144: 1066–1067.

    PubMed  CAS  Google Scholar 

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Correspondence to Emilio Fernández-Alvarez.

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Fernández-Alvarez, E. Movement disorders in children: Recent advances in management. Indian J Pediatr 76, 531–536 (2009). https://doi.org/10.1007/s12098-009-0138-6

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  • DOI: https://doi.org/10.1007/s12098-009-0138-6

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