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Gliomatosis cerebri

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Abstract

Gliomatosis cerebri is a rare and typically fatal tumor of neuroepithelial origin causing a diffuse infiltration of brain structures with mild or negligible destruction of parenchymal architecture. Very few cases have been reported in children. A 6-year-old boy who presented with worsening hemiplegia, behaviour problems and seizures after an episode of encephalitis-like illness is reported. MRI revealed diffuse signal change and swelling of the left cerebral hemisphere. The diagnosis of gliomatosis cerebri was confirmed by brain biopsy. Parents refused radiotherapy and the child worsened and died 6 months after diagnosis.

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References

  1. Armstrong GT, Phillips PC, Rorke-Adams LB et al. Gliomatosis cerebri: 20 years of experience at the Children’s Hospital of Philadelphia. Cancer 2006;107:1597–1606.

    Article  PubMed  Google Scholar 

  2. Jennings MT, Frenchman M, Shehab T et al. Gliomatosis cerebri presenting as intractable epilepsy during early childhood. J Child Neurol 1995;10:37–45.

    Article  PubMed  CAS  Google Scholar 

  3. Nevin S. Gliomatosis cerebri. Brain 1938;61:170–91.

    Article  Google Scholar 

  4. Lantos PL, Bruner JM. Gliomatosis cerebri. In Kleihues P, Cavenee WK eds. Pathology and genetics of tumors of the nervous system. Lyon; International agency for research on cancer, 1997;65–67.

    Google Scholar 

  5. Jayawant S, Neale J, Stoodley N, Wallace S. Gliomatosis cerebri in a 10-year old girl masquerading as diffuse encephalomyelitis and spinal cord tumor. Dev Med Child Neurol 2001;43:124–126.

    Article  PubMed  CAS  Google Scholar 

  6. del Carpio-O’Donovan R, Korah I, Salazar A, Melancon D. Gliomatosis cerebri. Radiology 1996;198:831–835.

    PubMed  Google Scholar 

  7. Pyhtinen J, Paakko E. A difficult diagnosis of gliomatosis cerebri. Neuroradiology 1996;38:444–448.

    Article  PubMed  CAS  Google Scholar 

  8. Artigas J, Cervos-Navarro J, Iglesias JR, Ebhardt G. Gliomatosis cerebri: clinical and histological findings. Clin Neuropathol 1985;4:135–148.

    PubMed  CAS  Google Scholar 

  9. Pal L, Behari S, Kumar S, Kumar R, Shankar SK, Gupta RK. Gliomatosis cerebri- an uncommon neuroepithelial tumor in children with oligodendroglial phenotype. Pediatr Neurosurg 2008;44:212–215.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India

    Suvasini Sharma & Veena Kalra

  2. Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India

    Ajay Garg

  3. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Vaishali Suri

  4. Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India

    Ashish Suri

Authors
  1. Suvasini Sharma
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  2. Veena Kalra
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  3. Ajay Garg
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  4. Vaishali Suri
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  5. Ashish Suri
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Correspondence to Suvasini Sharma.

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Sharma, S., Kalra, V., Garg, A. et al. Gliomatosis cerebri. Indian J Pediatr 76, 553–554 (2009). https://doi.org/10.1007/s12098-009-0090-5

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  • DOI: https://doi.org/10.1007/s12098-009-0090-5

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