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Indomethacin-induced colon perforation in Bartter’s syndrome

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Abstract

Bartter’s syndrome (BS) is an inherited renal tubular disorder characterized by hypokalemia, hypochloremic metabolic alkalosis, and hyperaldosteronism with normal blood pressure. A 22-year-old woman was referred at 23 week of gestation. Polyhydramnios was detected and the chloride level of the amniotic fluid was high. The mother was treated with indomethacin from 26 to 31 week of gestation. The newborn was delivered at 34 week of gestation. At 8th day of life, indomethacin was also started for the baby. After three days, a colonic perforation developed. Indomethacin-induced colon perforation is uncommon in antenatal Bartter’s syndrome. This patient indicates that administration of indomethacin in both antenatal and/or early postnatal period may be associated with colonic perforation.

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Authors and Affiliations

  1. Department of Neonatology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

    Emel Ataoglu, Ayse Ayaz Ozkul, Ipek Guney Varal & Elevli Murat

  2. Department of Pediatric Nephrology, Haseki Educational and Research Hospital, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

    Mahmut Civilibal

  3. Department of Pediatric Surgery, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey

    Elmas Reyhan Oktay

  4. Atakoy 7-8 Kisim, Mimar Sinan Sitesi, L5E Blok D: 49 34156 Atakoy, Istanbul, Turkey

    Mahmut Civilibal

Authors
  1. Emel Ataoglu
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  2. Mahmut Civilibal
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  3. Ayse Ayaz Ozkul
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  4. Ipek Guney Varal
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  5. Elmas Reyhan Oktay
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  6. Elevli Murat
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Corresponding author

Correspondence to Mahmut Civilibal.

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Ataoglu, E., Civilibal, M., Ozkul, A.A. et al. Indomethacin-induced colon perforation in Bartter’s syndrome. Indian J Pediatr 76, 322–323 (2009). https://doi.org/10.1007/s12098-009-0062-9

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  • DOI: https://doi.org/10.1007/s12098-009-0062-9

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