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Sevoflurane for central venous catheterization in non-intubated neonates

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Abstract

Objective

Sedation in neonates undergoing invasive prodedures as central venous catheterization (CVC) remains contro versial. Sevoflurane is an inhaled anesthetic whose periods of action and elimination are very short. The objective of this study was to evaluate the use of sevoflurane for sedation for central venous catheterization (CVC) in non-intubated neonates and preterms.

Methods

Thirty three (33) consecutive patients (range: 1–31 days old, 26 to 40 weeks GA, weighing 580 to 3200 g) were included over a 4 months period. Sevoflurane was progressively increased, until loss of consciousness and motor response to stimulation. FiO2, heart rate (HR), mean arterial pressure (MAP), duration of the procedure and the ease of the procedure were recorded.

Results

HR was very stable, but MAP dropped significantly. No patient required intubation. The ease of the procedure was scored as average 13 times and excellent 20 times.

Conclusion

The use of sevoflurane in neonates for CVC is feasible and achieve the goals of procedural sedation. The pharmacokinetic of sevoflurane enabled rapid adjustment of the depth of sedation. Sevoflurane appears to be a new agent at the disposal of neonatologists. Its use does not come without risks, especially for smaller preterms, which the treating clinician must anticipate.

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Authors and Affiliations

  1. Pediatric and Neonatal Intensive Care Unit, Department of Anesthesiology, North University Hospital, Marseille, France

    Renaud Vialet, Fabrice Michel, Sophie Hassid, Jean-Noël Di Marco & Claude Martin

  2. Reanimation Pediatrique et Neonatale Department d’Anesthesie-Reanimation CHU Nord Boulevard Pierre Dramrd, 13015, Marseille, France

    Renaud Vialet

Authors
  1. Renaud Vialet
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  2. Fabrice Michel
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  3. Sophie Hassid
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  4. Jean-Noël Di Marco
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  5. Claude Martin
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Correspondence to Renaud Vialet.

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Vialet, R., Michel, F., Hassid, S. et al. Sevoflurane for central venous catheterization in non-intubated neonates. Indian J Pediatr 76, 273–277 (2009). https://doi.org/10.1007/s12098-009-0012-6

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  • DOI: https://doi.org/10.1007/s12098-009-0012-6

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