Role of colostrum in gastrointestinal infections

Abstract

Colostrum is breast milk produced after the birth of the newborn and lasts for 2–4 days. Colostrum is very important part of breast milk and lays down the immune system and confers growth factors and other protective factors for the young ones in mammals. This is the source of passive immunity transferred to the baby from the mother. The biological value of bovine colostrum in present day medical practice is documented in clinical trials and large databases containing case reports and anecdotal findings. The main actions include an antibacterial effect and modulation of immune response with the ability to neutralize lipopolysaccharides arising from gram negative bacterial pathogens. It has been found to be effective in infantile hemorrhagic diarrheas, other diarrheas and reduces the likelihood of disease progressing to hemolytic uremic syndrome. It has also been tested in H pylori infection and diarrhea in immunodeficiency. Side effects of clinical relevance are limited to possible intolerance due to lactose and sensitivity to milk proteins.

References

  1. 1.

    Kaushik S, Trivedi SS, Jain A, Bhattcharjee J. Unusual changes in colostrum composition in lactating Indian women having medical complication during pregnancy-A pilot study. Indian J Clin Biochem 2002; 17: 68–73.

    Article  Google Scholar 

  2. 2.

    Pakkanen R, Aalto J. Review paper-Growth factors and antimicrobial factors in bovine colostrum. Internat Diary J 1997; 7: 285–297.

    Article  CAS  Google Scholar 

  3. 3.

    Boesman-Finkelstein M, Finkelstein R. Passive oral immunization in children. Lancet 1989; 2: 1336.

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Dicthtelmuller W, Lissner R. Antibodies from colostrum in oral immunotherapy. J Clin Biochem 1990; 28: 19–23.

    Google Scholar 

  5. 5.

    Ogra SS, Ogra PL. Immunological aspects of human colostrum and milk. J Pediatr 1978; 92: 546–549.

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Antonius C M., van Hoojidonk, Kussendrager K D, Steijns J M. In vivo antimicrobial and antiviral activity of components in bovine mild and colostrum involved in non-specific defence. Br J Nutr 2000; 84 (S-1): S127–S134.

    Google Scholar 

  7. 7.

    Davidson G, Whyte P, Daniels E et al. Passive immunization of children with bovine colostrum containing antibodies to human rotavirus. Lancet 1989; 2: 709–712.

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Bitzan M M, Gold B D, Phil Pott D J et al. Inhibition of H pylori and Helicobactor mustelae binding to lipid receptors by bovine colostrum. J Infect Dis 1998; 177: 955–961.

    PubMed  CAS  Google Scholar 

  9. 9.

    Bogstedt A K, Johansen K, Hatta H et al. Passive immunity against diarrhea. Acta Pediatr 1996; 85: 125–128.

    Article  CAS  Google Scholar 

  10. 10.

    Lonnedal B, Iyer S. Lactoferrin molecular structure and biological function. Ann Review Nutr 1995; 15: 93–100.

    Article  Google Scholar 

  11. 11.

    Bocc V, Von Breeman K, Corradeschi F et al. What is the role of cytokines in human colostrum? J Bio Regulat Homeo Agents 1991; 3: 121–124.

    Google Scholar 

  12. 12.

    Lawton J W, Shortstride K F, Wong R Ng Mh. Interferon synthesis by human Colostral leucocytes. Arch Dis childhood 1979; 54: 127–130.

    CAS  Google Scholar 

  13. 13.

    Bhora F, Dinkin B, Batzri S et al. Effect of growth factors on cell proliferation and epithelization in human skin. J Surg Res 1995; 59: 236–244.

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Francis G, Upton F, Ballard J et al. Insulin like growth factors 1 and 2 in bovine colostrums. J Biochem 1988; 251: 95–103.

    CAS  Google Scholar 

  15. 15.

    Thapa B R. Health factors in colostrum. Indian J Pediatr 2005; 72: 579–581.

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Mero A, Kahkonen, Nykanen T et al. IGF-I, IgA and IgG responses to bovine colostrums supplementation during training. J Appl Physiol 2002; 93: 732–739.

    PubMed  CAS  Google Scholar 

  17. 17.

    Bocc V, Von Bremen K, Corradeschi F et al. What is the role of cytokines in human colostrum? J Bio Regulat Homeo Agents 1991; 3: 121–124.

    Google Scholar 

  18. 18.

    Ahmed L, Nazrul Islam SK, Khan NI, Nahid SN. Vitamin C Content in Human Milk (Colostrum, Transitional and Mature) and serum of a sample of Bangladeshi Mothers. Mal J Nutr 2004; 10: 1–4.

    Google Scholar 

  19. 19.

    Mitra A K, Mahatanabis D, Ashraf H et al. Hyperimmune cow colostrums reduces diarrhea due to rotavirus: a doubleblind, controlled clinical trial. Acta Pediatr 1995; 84: 996–1001.

    Article  CAS  Google Scholar 

  20. 20.

    Sarkar S A, Casswall T H, Mahalanabis D’et al. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J 1998, 17: 1149–1154.

    Article  Google Scholar 

  21. 21.

    Brussow H. Hilpert H. Walther I. Sidoti J. Mietens C. Bachmann P. Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis. J Clin Microbiol 1987; 25: 982–986.

    PubMed  CAS  Google Scholar 

  22. 22.

    Tzipori S, Roberson D, Chapman C. Remission of diarrhea due to cryptosporidiosis in an immunodeficient child treated with hyperimmune bovine colostrums. BMJ 1986; 293: 1276–1277.

    PubMed  CAS  Article  Google Scholar 

  23. 23.

    Tzipori S, Robertson D, Cooper DA, While L. Chronic cryposporidial diarrhea and hyperimmue cow colostrums. Lancet 1987; 2: 344–345.

    PubMed  Article  CAS  Google Scholar 

  24. 24.

    Nord J, Ma P, Dijohn D, Tzipori S, Tacket Co. Treatment with bovine hyperimmune colostrums of cryptosporidial diarrhea in AIDS patients. AIDS 1990; 4: 581–584.

    PubMed  Article  CAS  Google Scholar 

  25. 25.

    Ungar BL, Ward DJ, Fayer R, Quinn CA. Cessation of Cryprosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrums. Gastroenterology 1990; 98: 486–489.

    PubMed  CAS  Google Scholar 

  26. 26.

    Rump JA, Amdt R, Arnold A, Bendick C, Dichtelmuller H. Franke M et al. Treatment of diarrhea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrums. Clin Invest 1992; 70: 588–594.

    Article  CAS  Google Scholar 

  27. 27.

    Lissner R, Schmidit H, Karch H. A standard immunoglobulin preparation produced from bovine colostra shows antibody reactivity and neutralization activity against shiga like toxin and EHEC hemolysin of Escherichia coli 0157: H7. J Infection 1996; 24: 378–383.

    Article  CAS  Google Scholar 

  28. 28.

    Huppertz, HI, Rutkowski S, Busch DH et al. Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin producing E. coli and E. coli expressing intimin and hemolysin. J Pediatr Gastroenterol Nutr 1999; 29: 452–456.

    PubMed  Article  CAS  Google Scholar 

  29. 29.

    Bolke E, Jehle PM, Hausmann F et al. Preoperative oral application of immunoglobulin-enriched colostrum milk and mediator response during abdominal surgery. Shock 2002; 17: 9–12.

    PubMed  Article  Google Scholar 

  30. 30.

    Bolke E, Orth K, Jehle PM et al. Enteral application of immunoglobulin-enriched colostrum milk preparation for reducing endotoxin translocation and acute phase response in patients undergoing coronary bypass surgery-a randomized placebo controlled trial. Wien Klin Wochenschr 2002; 114: 923–928.

    PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to B. R. Thapa.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rawal, P., Gupta, V. & Thapa, B.R. Role of colostrum in gastrointestinal infections. Indian J Pediatr 75, 917 (2008). https://doi.org/10.1007/s12098-008-0192-5

Download citation

Key words

  • Colostrum
  • Bovine colostrum
  • GI infections