Abstract
Objective
Poisoning does the most serious damages in pediatrics. In the northeast of Iran (Golestan province), opium is used widely for symptomatic therapy of routine illnesses in young children by parents. In the present study, opium toxicity was assessed in young children referred to pediatric centers in our area.
Methods
This survey was done as a prospective cross-sectional study. At first, a pilot study was undertaken to estimate the condition of opium intoxicated children and evaluate the validity of questionnaire. We collected data in collaboration with committee of Adverse Drug Reactions (ADR) in Golestan Province. All members of ADR committee in pediatric centers were trained to complete questionnaires in referred or admitted children under-5-year. Data was entered into computer and analyzed by Chi-square and Fisher exact test.
Results
In this survey, 67 opium-intoxicated children were recruited. Minimum age of the cases was 6 days and maximum 5-year. Uneducated mothers, in most cases, gave opium to the child. Most of them were from the low socio-economic level. Ethnic was disparity was observed. Four deaths occurred.
Conclusion
As the results showed, opioids are dangerous in pediatric population, especially under 5-year. Respiratory depression, bradypnea, coma and death are the serious outcomes of opium toxicity in pediatrics. Such a practice of unrestricted use of opium contributes to children mortality and so it is essential to launch educational programs.
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References
Reingardiene D, Vilcinskaite J. Opioid overdose. Medicina (kaunas) 2002; 38: 948–955.
Kadivar M, Javadinia N, Nemati N. A survey on opium & its derivatives poisoning in Children’s Hospital Medical Center. J Med Council Islamic Republic Iran 2000; 2: 100–106.
Moghadamnia AA, Abdollahi M. An epidemiological study of poisoning in northern Islamic Republic of Iran. East Mediterr Health J 2002; 8: 88–94.
IMRAN M, UPPAL TB. Opium administration to infants in Peshawar region of Pakistan; UNODC. Bulletin Narcotics 1979; 3: 69–75.
Abnet CC, Saadatian-Elahi M, Pourshams A et al. Reliability and validity of opiate use self-report in a population at high risk for esophageal cancer in Golestan, Iran. Cancer Epidemiol Biomarkers Prev 2004; 13: 1068–1070.
Sharma V, Saxena S. Accidental poisoning in children in Jaipur. Indian Pediatr 1974; 11: 174–178.
Sitaraman S, Sharma V, Saxena S. Accidental poisoning in children. Indian Pediatr 1985; 22: 757–760.
Jalali N, Abdollahi M, Sharifzadeh M, Nazi S, Baradaran M. Mortality and morbidity of poisoning due to opium and its derivatives at Loghman Hakim Hospital Poison Center, 1994. Pejouhandeh Quarterly Res J 1998; 4: 17–19.
RJ Flanagan, C Rooney, C Griffiths Fatal Poisoning in Childhood, England and Wales 1968–2000, Forensic Science International 2005; 148: 121–129.
Hassanian-Moghaddam H, Pajoumand A, Dadgar SM, Shadnia Sh. Prognostic factors in methanol poisoning. Hum Exp Toxicol 2007; 26: 583–586.
Kumar V. Accidental poisoning in South West Maharashtra. Indian Pediatr 1991; 28: 731–735.
Ghosh S, Aggarwal VP. Accidental poisoning in childhood with particular reference to kerosene. J Indian Med Assoc 1962; 39: 635–639.
Aggarwal V, Gupta A. Accidental poisoning in children. Indian Pediatr 1974; 11: 617–621.
Buhariwall RJ, Sanjanwalla. Poisoning in children [A study of 303 cases]. Indian Pediatr 1969; 6: 141–145.
Motlagh ME, Nazari Z. Epidemiologic study of pediatric poisonings in Amir Kabir and Abozar Hospital of Ahwaz in the year 2000. J Legal medicine Islamic republic Iran 2002; 27: 42–39.
Wiseman HM, Guest K, Murray VSG, Volans GN. Accidental poisoning in childhood: A multicentre survey. I. General epidemiology. Hum Exp Toxicol 1987; 6: 293–301.
Singh S, Narang A, Walia BNS, Mehta S, Lata Kumar. Accidental poisoning in children: 10 years experience. Indian Pediatr 1981; 18: 163–166.