Skip to main content

Advertisement

Log in

Blood component therapy

  • Symposium on Advances in Hematology
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

The blood component support in pediatric patients is more challenging as compared to adult patients, as such, a thorough understanding of various blood components and indications for each is critical when making the decision for transfusion. Transfusion needs in pediatric group parallel the changes that accompany the transitions from fetus to neonate, neonate to infant, and throughout childhood. Modified or unmodified blood components viz. red blood cells, platelets, granulocytes, fresh frozen plasma and cryoprecipitate are required for transfusion support in pediatric population. In general, fetuses and infants younger than 4 months of age have specialized transfusion requirements whereas transfusion of infants older than 4 months and children parallels those for adults. Transfusion practices differ widely among pediatric care units depending upon individual preferences, hospital transfusion policy and resource availability. There is a need to implement best transfusion practices and despite the lack of firm evidences, existing pediatric transfusion guidelines can help pediatric care providers in their decisions related to component transfusion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. British Committee for Standards in Haematology: Transfusion guidelines for neonates and older children. Br J Haematol 2004; 124: 433–453.

    Article  Google Scholar 

  2. Hershey MD, Glas DD. Con: whole blood transfusions are not useful in patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth 1992; 6: 761–763.

    Article  PubMed  CAS  Google Scholar 

  3. British Committee for Standards in Haematology Blood Transfusion Task Force. Guidelines for administration of blood products: transfusion of infants and neonates. Transfusion Medicine 1994; 4: 63–69.

    Article  Google Scholar 

  4. American Association of Blood Banks (AABB). Bethesda. USA; Technical Manual, 14th ed. 2002.

  5. Roseff SD, Luban NL, Manno CS: Guidelines for assessing appropriateness of pediatric transfusion. Transfusion 2002; 42: 1398–1413.

    Article  PubMed  Google Scholar 

  6. Moise Jr KJ. Management of rhesus alloimmunization in pregnancy. Obstet Gynecol 2002; 99: 589–593.

    Article  Google Scholar 

  7. Elgelfriet CP, Reesink HW, Kroll H et al. Prenatal management of alloimmune thrombocytopenia of the fetus. Vox Sang 2003; 84: 142–149.

    Article  Google Scholar 

  8. Luban NLC, Strauss RG, Hume HA. Commentary on the safety of red blood cells preserved in extended storage media for neonatal transfusions. Transfusion 1991; 31: 229–235.

    Article  PubMed  CAS  Google Scholar 

  9. Strauss RG. Data-driven blood banking practices for neonatal RBC transfusions. Transfusion 2000; 40: 1528–1540.

    Article  PubMed  CAS  Google Scholar 

  10. American Society of Anesthesiologists Task Force on Blood Component Therapy. Practice guidelines for blood component therapy. Anesthesiology 1996; 84: 732–747.

    Article  Google Scholar 

  11. Northern Neonatal Nursing Initiative Trial Group. Randomised trial of prophylactic early fresh-frozen plasma, gelatin or glucose in pre-term babies: outcome at 2 years. Lancet 1996; 348: 229–232.

    Article  Google Scholar 

  12. Ramasethu J, Luban NLC. T activation. Br J Haematol, 2001; 112: 259–263.

    Article  PubMed  CAS  Google Scholar 

  13. Strauss RG. Transfusion therapy for neonates. Am J Dis Child 1991; 145: 904–911.

    PubMed  CAS  Google Scholar 

  14. Stehling L, Luban NLC, Anderson KC et al. Guidelines for blood utilization review. Transfusion 1994; 34: 438–448.

    Article  PubMed  CAS  Google Scholar 

  15. Prati D. Benefits and complications of regular blood transfusion in patients with beta-thalassaemia major. Vox Sang 2000; 79: 129–137.

    Article  PubMed  CAS  Google Scholar 

  16. Ohene-Frempong K. Indications for red cell transfusion in sickle cell disease. Semin Hematol 2001; 38: 5–13.

    Article  PubMed  CAS  Google Scholar 

  17. Kevy SV. Red cell transfusion. In Nathan DG, Oski FA, Eds. Hematology of infancy and childhood. 4th ed. Philadelphia; W.B. Saunders, 1993; 1769–1780.

    Google Scholar 

  18. McCullough J. Collection and use of stem cells: role of transfusion centers in bone marrow transplantation. Vox Sang 1994; 67 (S3): 35–42.

    Article  PubMed  Google Scholar 

  19. Kemmotsu H, Joe K, Nakamura H, Yamashita M. Predeposited autologous blood transfusion for surgery in infants and children. J Pediatr Surg 1995; 30: 659–661.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anupam Verma.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Verma, A., Hemlata Blood component therapy. Indian J Pediatr 75, 717–722 (2008). https://doi.org/10.1007/s12098-008-0136-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-008-0136-0

Key words

Navigation