Skip to main content
SpringerLink
Log in

Familial systemic lupus erythematosus with hypercalcemia

  • Clinical Brief
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

An 8-yr-old girl with familial systemic lupus erythematosus and several severe manifestations, including persistent thrombocytopenia, rapidly progressive renal failure and hepatic failure is described. The course was complicated by the occurrence of hypercalcemia, hypophosphatemia and elevated levels of parathormone, an association not previously reported in children.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Galrao LD, Lima IV, Santos L, Santiago MB. Primary hyperparathyroidism in a patient with systemic lupus erythematosus. Arq Bras Endocrinol Metabol 2004; 48: 555–558.

    PubMed  Google Scholar 

  2. Gazzaruso C, Montecucco CM, Geroldi D, Garzaniti A, Finardi G. Severe hypercalcemia and systemic lupus erythematosus. Joint Bone Spine 2000; 67: 485–488.

    PubMed  CAS  Google Scholar 

  3. Deftos LJ, Burton DW, Baird SM, Terkeltaub RA. Hypercalcemia and systemic lupus erythematosus. Arthritis Rheum 1996; 39: 2066–2069.

    Article  PubMed  CAS  Google Scholar 

  4. Erdozain JG, Egurbide MV, Ruiz-Irastorza G, Ojanguren J, Aguirre C. Systemic lupus erythematosus presenting as acute symptomatic hypercalcemia. Lupus 2004: 13: 132–134.

    Article  PubMed  CAS  Google Scholar 

  5. Farah R, Farah R, Makhoul N. Severe hypercalcemia as a presenting sign of systemic lupus erythematosus. Eur J Intern Med 2006; 17: 206–208.

    Article  PubMed  Google Scholar 

  6. Scofield RH, Bruner GR, Kelly JA, Kilpatrick J, Bacino D, Nath SK et al. Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13. Blood 2003; 101: 992–997.

    Article  PubMed  CAS  Google Scholar 

  7. Ward MM, Pajevic S, Dreyfuss J, Malley JD. Short term prediction of mortality in patients with systemic lupus erythematosus: classification of outcomes using random forests. Arthritis Rheum 2006; 55: 74–80.

    Article  PubMed  Google Scholar 

  8. Arnett FC, Reichlin M. Lupus hepatitis: an under-recognized disease feature associated with autoantibodies to ribosomal P. Am J Med 1995; 99: 465–472.

    Article  PubMed  CAS  Google Scholar 

  9. Lyon AJ, McIntosh N, Wheeler K, Brooke OG. Hypercalcemia in extremely low birthweight infants. Arch Dis Child 1984; 59: 1141–1144.

    Article  PubMed  CAS  Google Scholar 

  10. Pallais JC, Kifor O, Chen YB, Slovik B, Brown EM. Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor. N Engl J Med 2004; 351: 362–369.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

    Utkarsh Kohli, Rakesh Lodha & Arvind Bagga

Authors
  1. Utkarsh Kohli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rakesh Lodha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Arvind Bagga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Arvind Bagga.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kohli, U., Lodha, R. & Bagga, A. Familial systemic lupus erythematosus with hypercalcemia. Indian J Pediatr 75, 855–857 (2008). https://doi.org/10.1007/s12098-008-0106-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-008-0106-6

Key words

Search

Navigation