Skip to main content


Log in

Typhoid fever and viral hepatitis

  • Clinical Brief
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript


Feco-oral route is the most common mode of transmission for both enteric fever and hepatitis A and E, and thus infection by these agents may occur concurrently especially in tropical endemic areas like India. In this scenario, there occurs a diagnostic dilemma with respect to differentiation from ‘typhoid hepatitis’, the hepatic manifestations of typhoid fever. We herein present such a case and discuss pertinent issues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.


  1. Schwartz E, Jenks NP, Shilm DR. Typhoid hepatitis or typhoid fever and acute viral hepatitis. Trans R Soc Trop Med Hyg 1994; 88: 437–438.

    Article  CAS  PubMed  Google Scholar 

  2. Pandey CK, Singh N, Kumar V, Aggarwal A, Singh PK. Typhoid, hepatitis E, or typhoid and hepatitis E: The cause of fulminant hepatic failure — A diagnostic dilemma. Crit Care Med 2002; 376–378.

  3. Kundu AK. Typhoid hepatitis. J Assoc Physicians India 2002; 50: 719–720.

    CAS  PubMed  Google Scholar 

  4. Ramachandran S, Godfrey JJ, Perera MVF. Typhoid hepatitis. JAMA 1974; 230: 236–240.

    Article  CAS  PubMed  Google Scholar 

  5. Khosla SN, Singh R, Singh GP, Trehan VK. The spectrum of hepatic injury in enteric fever. Am J Gastroenterol 1988; 83: 413–416.

    CAS  PubMed  Google Scholar 

  6. Quak SH, Sibal A, Chang MH. Liver disease in the developing world. In Kelly DA eds. Diseases of the Liver and Biliary System in Children, 2nd ed. London; Blackwell Scientific, 2004; 421–438.

    Google Scholar 

  7. Morgenstern R, Hayes PC. The liver in typhoid fever: Always affected, not just a complication. Am J Gastroenterol 1991; 86: 1235–1238.

    CAS  PubMed  Google Scholar 

  8. Khan M, Coovadia YM, Karas JA et al. Clinical significance of hepatic dysfunction with jaundice in typhoid fever. Dig Dis Sci 1999; 44: 590–594.

    CAS  PubMed  Google Scholar 

  9. El-Newihi HM, Alamy ME, Reynolds TB. Salmonella hepatitis: analysis of 27 cases and comparison with acute viral hepatitis. Hepatology 1996; 24: 516–519.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Devendra Mishra.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mishra, D., Chaturvedi, D. & Mantan, M. Typhoid fever and viral hepatitis. Indian J Pediatr 75, 509–510 (2008).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

Key words