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Multidrug — resistant typhoid fever

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Abstract

Objective

To study the epidemiological pattern, clinical picture, the recent trends of multidrug-resistant typhoid fever (MDRTF), and therapeutic response of ofloxacin and ceftriaxone in MDRTF.

Methods

The present prospective randomized controlled parallel study was conducted on 93 blood culture-proven Salmonella typhi children. All MDRTF cases were randomized to treatment with ofloxacin or ceftriaxone.

Results

Of 93 children, 62(66.6%) were MDRTF. 24 cases were below 5 years, 26 between 5–10 years and 12 were above 10 years. Male to female ratio was 1.85: 1. Majority of cases came from lower middle socio-economic classes with poor personal hygiene. Fever was the main presenting symptom. Hepatomegaly and splenomegaly was present in 88% and 46% cases respectively. 19(30.6%) cases developed complications. Mean defervescence time with ceftriaxone and ofloxacin was 4.258 and 4.968 days respectively.

Conclusion

MDRTF is still emerging as serious public and therapeutic challenge. Ceftriaxone is well-tolerated and effective drug but expensive whereas ofloxacin is safe, cost-effective and therapeutic alternative in treatment of MDRTF in children with comparable efficacy to ceftriaxone.

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Authors and Affiliations

  1. Department of Pediatrics, Batra Hospital & Medical Research Centre, New Delhi, 110 062, India

    Rajiv Kumar, Nomeeta Gupta &  Shalini

  2. Department of Pharmacology, Maulana Azad Medical College, New Delhi, India

    Shalini

Authors
  1. Rajiv Kumar
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  2. Nomeeta Gupta
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  3. Shalini
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Corresponding author

Correspondence to Rajiv Kumar.

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Kumar, R., Gupta, N. & Shalini Multidrug — resistant typhoid fever. Indian J Pediatr 74, 39–42 (2007). https://doi.org/10.1007/s12098-007-0024-z

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