Skip to main content

Advertisement

SpringerLink
Log in

Impact of obesity on in-hospital mortality and morbidity among patients admitted for antineoplastic chemotherapy: a nationwide analysis

  • RESEARCH ARTICLE
  • Published:
Clinical and Translational Oncology Aims and scope Submit manuscript

Abstract

Background

Obesity is a complex and multifactorial medical condition that can have far reaching consequences on cancer patients, particularly those undergoing treatment such as chemotherapy. Our study focuses to comprehensively explore the various adverse outcomes in obese patients receiving chemotherapy during hospitalization.

Methods

The National Inpatient Sample 2020 was used using the ICD-10 codes to identify patients hospitalized with a primary discharge diagnosis of neoplastic chemotherapy with or without a secondary diagnosis of obesity. Statistical analysis using Stata software was done, and primary and secondary outcomes were obtained after adjusting for confounders using multivariate regression analysis.

Results

Mortality was similar in both obese and non-obese patients. Length of stay and total hospitalization charges were increased in obese patients. Obese patients had higher odds of developing acute respiratory failure and were more likely to require non-invasive and invasive mechanical ventilation.

Conclusion

Our study concluded that obesity could be considered an independent predictor of worse outcomes in patients admitted for neoplastic chemotherapy. Notably, addressing obesity could help to improve the efficacy of treatment for cancer patients while simultaneously reducing any negative consequences associated with being obese.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data availability

The datasets generated and/or analyzed during the current study are available at https://hcupus.ahrq.gov/databases.jsp.

References

  1. Dollinger M. Guidelines for hospitalization for chemotherapy. Oncologist. 1996;1(1 & 2):107–11 (PMID: 10387975).

    Article  CAS  PubMed  Google Scholar 

  2. Kalaycio M. Inpatient management of acute leukemia. Cleve Clin J Med. 1997;64(7):385–9. https://doi.org/10.3949/ccjm.64.7.385. (PMID: 9223768).

    Article  CAS  PubMed  Google Scholar 

  3. Sannu A, Radha R, Mathews A, Padmakumari Mony R, Prahladan A, James FV. Ifosfamide-induced malignancy of ureter and bladder. Cureus. 2017;9(8): e1594. https://doi.org/10.7759/cureus.1594.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Pendergrass TW, Milstein JM, Geyer JR, Mulne AF, Kosnik EJ, Morris JD, et al. Eight drugs in one day chemotherapy for brain tumors: experience in 107 children and rationale for pre radiation chemotherapy. J Clin Oncol. 1987;5(8):1221–31. https://doi.org/10.1200/JCO.1987.5.8.1221. (PMID: 3040919).

    Article  CAS  PubMed  Google Scholar 

  5. Dumas JF, Brisson L. Interaction between adipose tissue and cancer cells: role for cancer progression. Cancer Metastasis Rev. 2021;40(1):31–46. https://doi.org/10.1007/s10555-020-09934-2. (Epub 2020 Oct 2 PMID: 33009650).

    Article  CAS  PubMed  Google Scholar 

  6. Furlanetto J, Eiermann W, Marmé F, Reimer T, Reinisch M, Schmatloch S, et al. Higher rate of severe toxicities in obese patients receiving dose-dense (dd) chemotherapy according to unadjusted body surface area: results of the prospectively randomized GAIN study. Ann Oncol. 2016;27(11):2053–9. https://doi.org/10.1093/annonc/mdw315. (Epub 2016 Aug 8 PMID: 27502721).

    Article  CAS  PubMed  Google Scholar 

  7. IARC Working Group. The evaluation of cancer-preventive interventions. Absence of excess body fatness. , Lyon: International Agency for Research on Cancer; 2021.

    Google Scholar 

  8. Pothiwala P, Jain SK, Yaturu S. Metabolic syndrome and cancer. Metab Syndr Relat Disord. 2009;7(4):279–88. https://doi.org/10.1089/met.2008.0065.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJ, Comparative Risk Assessment Collaborating Group. Selected major risk factors and global and regional burden of disease. Lancet. 2002;360(9343):1347–60. https://doi.org/10.1016/S0140-6736(02)11403-6. (PMID: 12423980).

    Article  PubMed  Google Scholar 

  10. Anis AH, Zhang W, Bansback N, Guh DP, Amarsi Z, Birmingham CL. Obesity and overweight in Canada: an updated cost-of-illness study. Obes Rev. 2010;11(1):31–40. https://doi.org/10.1111/j.1467-789X.2009.00579.x. (Epub 2009 Apr 21 PMID: 19413707).

    Article  CAS  PubMed  Google Scholar 

  11. Costa-Font J, Gil J. Obesity and the incidence of chronic diseases in Spain: a seemingly unrelated probit approach. Econ Hum Biol. 2005;3(2):188–214. https://doi.org/10.1016/j.ehb.2005.05.004. (PMID: 15941678).

    Article  PubMed  Google Scholar 

  12. Petrelli F, Cortellini A, Indini A, Tomasello G, Ghidini M, Nigro O, et al. Association of obesity with survival outcomes in patients with cancer: a systematic review and meta-analysis. JAMA Netw Open. 2021;4(3): e213520. https://doi.org/10.1001/jamanetworkopen.2021.3520.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Ramdass V, Caskey E, Sklarz T, Ajmeri S, Patel V, Balogun A, et al. Association between obesity and cancer mortality: an internal medicine outpatient clinic perspective. J Clin Med Res. 2021;13(7):377–86. https://doi.org/10.14740/jocmr4543.PMID:34394780,PMCID:PMC8336943.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348(17):1625–38. https://doi.org/10.1056/NEJMoa021423. (PMID: 12711737).

    Article  PubMed  Google Scholar 

  15. Pasquale MK, Sun SX, Song F, Hartnett HJ, Stemkowski SA. Impact of exacerbations on health care cost and resource utilization in chronic obstructive pulmonary disease patients with chronic bronchitis from a predominantly Medicare population. Int J Chron Obstruct Pulmon Dis. 2012;7:757–64. https://doi.org/10.2147/COPD.S36997.PMID:23152680;PMCID:PMC3496536.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Wyckoff Heights Medical Center, 374 Stockholm St, Brooklyn, NY, 11237, USA

    Saad Javaid

  2. A.T. Still University School of Osteopathic Medicine (Mesa, AZ), 5850 E, Still Circle, Mesa, AZ, 85206, USA

    Kelly Frasier

  3. Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA

    Ammad Javaid Chaudhary

Authors
  1. Saad Javaid
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kelly Frasier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ammad Javaid Chaudhary
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Saad Javaid.

Ethics declarations

Conflict of interest

Authors have no competing interests to disclose.

Ethics Approval

HCUP Databases Are Limited Data Sets that do not include patients' identification, consent or review by an institutional review board (IRB) is not required for use of limited data sets.

Informed consent

For this type of study, formal consent is not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Javaid, S., Frasier, K. & Chaudhary, A.J. Impact of obesity on in-hospital mortality and morbidity among patients admitted for antineoplastic chemotherapy: a nationwide analysis. Clin Transl Oncol 26, 977–984 (2024). https://doi.org/10.1007/s12094-023-03335-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12094-023-03335-x

Keywords

Search

Navigation