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Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas

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Abstract

Purpose

The purpose of the study was to evaluate the prognostic value of low T3 syndrome in peripheral T-cell lymphomas (PTCLs).

Methods

One hundred and seventy-four patients of newly diagnosed PTCLs were enrolled in the study. We performed statistical analysis based on the clinical data collected.

Results

Thirty-Six (20.69%) patients had low T3 syndrome at first admission. Results suggested that the patients with higher score of ECOG PS, International Prognostic Index (IPI) and Prognostic Index for T-cell lymphoma (PIT), bone marrow involvement and lower level of albumin tended to develop low T3 syndrome. The median progression-free survival (PFS) and overall survival (OS) were 10 months and 36 months, respectively, for all patients. Pre-existing low T3 syndrome was in correlation with worse PFS and OS. Patients with low T3 syndrome showed worse PFS (4 months vs 13 months, P = 0.0001) and OS (7 months vs 83 months, P < 0.0001) than patients without low T3 syndrome. IPI and PIT, respectively, combined with low T3 syndrome improved the ability to predict OS and PFS of PTCLs.

Conclusions

The study indicated that low T3 syndrome may be a good candidate for predicting prognosis of peripheral T-cell lymphomas.

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Data availability

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (81800192, 82200887), Science and Technology Department of Jiangsu Province (BK20220716), and China Postdoctoral Science Foundation (2022M711404).

Author information

Author notes

  1. Wenyi Li and Rui Gao contributed equally to this work.

Authors and Affiliations

  1. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China

    Wenyi Li, Weiting Wang, Jing Tang, Hua Yin, Jiazhu Wu, Jinhua Liang, Yue Li, Li Wang, Jianyong Li, Haorui Shen & Wei Xu

  2. Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, China

    Wenyi Li, Weiting Wang, Jing Tang, Hua Yin, Jiazhu Wu, Jinhua Liang, Yue Li, Li Wang, Jianyong Li, Haorui Shen & Wei Xu

  3. Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China

    Wenyi Li, Weiting Wang, Jing Tang, Hua Yin, Jiazhu Wu, Jinhua Liang, Yue Li, Li Wang, Jianyong Li, Haorui Shen & Wei Xu

  4. Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China

    Rui Gao

Authors
  1. Wenyi Li
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were mainly performed by WL, RG, WW and JT. The first draft of the manuscript was written by WL and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Haorui Shen or Wei Xu.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

The study was approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University. All aspects of this study, including the measurement of serum thyroid hormone levels such as serum free T3 (FT3), free T4 (FT4) and TSH, and other clinical and laboratorial checkups, were performed in accordance with the principles of the Declaration of Helsinki (64th, 2013).

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All persons gave their informed consent prior to their inclusion in the study.

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Li, W., Gao, R., Wang, W. et al. Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas. Clin Transl Oncol 26, 613–622 (2024). https://doi.org/10.1007/s12094-023-03280-9

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  • DOI: https://doi.org/10.1007/s12094-023-03280-9

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