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Induction of perineural invasion in salivary adenoid cystic carcinoma by circular RNA RNF111

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Abstract

Objective

Local recurrence, distant metastasis, and perineural invasion (PNI) viciously occur in salivary adenoid cystic carcinoma (SACC), resulting in a poor prognosis. This study aimed to explore the mechanism by which circular RNA RNF111 (circ-RNF111) regulates PNI in SACC by targeting the miR-361-5p/high mobility group box 2 (HMGB2) axis.

Method

Circ-RNF111 and HMGB2 were highly expressed in SACC specimens, while miR-361-5p was underexpressed. Functional experiments showed that ablating circ-RNF111 or promoting miR-361-5p hindered the biological functions and PNI of SACC-LM cells.

Results

HMGB2 overexpression induced the reversal of SACC-LM cell biological functions and PNI caused by circ-RNF111 knockout. Furthermore, reduction of circ-RNF111 suppressed PNI in a SACC xenograft model. Circ-RNF111 regulated HMGB2 expression through targeted modulation of miR-361-5p.

Conclusion

Taken together, circ-RNF111 stimulates PNI in SACC by miR-361-5p/HMGB2 axis and may serve as a potential therapeutic target for SACC.

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Data availability

The data and materials used to support the findings of this study are available from the corresponding author.

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Authors and Affiliations

  1. Department of Stomatology, Longyan People’s Hospital, Longyan, 364000, Fujian, China

    RongBin Su, ShuSheng Zhong & PengHui Wang

  2. Department of Radiology, Longyan People’s Hospital, No. 31, Denggao West Road, Xinluo District, Fujian Province, 364000, Longyan, China

    ZhongWei Lin

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Correspondence to ZhongWei Lin.

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This study was approved by the Ethics Committee of Longyan People's Hospital (Approval number: 20150308LY), and written informed consent was obtained from all participants.

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Su, R., Zhong, S., Wang, P. et al. Induction of perineural invasion in salivary adenoid cystic carcinoma by circular RNA RNF111. Clin Transl Oncol 25, 3152–3164 (2023). https://doi.org/10.1007/s12094-023-03182-w

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  • DOI: https://doi.org/10.1007/s12094-023-03182-w

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