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Dual effects of circRNA in thyroid and breast cancer

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Abstract

CircRNA, the latest research hotspot in the field of RNA, is a special non-coding RNA molecule, which is unable to encode proteins and bind polyribosomes. As a regulatory molecule, circRNA participates in cancer cell generation and progression mainly through the mechanism of competitive endogenous RNA. In numerous regulated cancer organs, the thyroid and breast are both endocrine organs, and both are regulated by the hypothalamic pituitary gland axis. Thyroid cancer (TC) and breast cancer (BC) are both sexually prevalent in women and both are affected by hormones, thus they are intrinsically linked. In addition, recent epidemiological surveys have found that, early metastasis and recurrence of breast cancer remain the main cause of survival in breast cancer patients. Although at home and abroad, studies have shown that new targeted anti-tumor drugs with numerous tumor markers are gradually being used in the clinic, evidence for potential molecular mechanisms affecting its prognosis lacks clinical studies. Therefore, we search the relevant literature, and based on the latest domestic and international consensus, review the molecular mechanisms and regulation relevance of circRNA, compare the difference of the same circRNA in two tumors, to more deeply understand and lay the foundation for future clinical diagnostic, therapeutic and prognostic studies in large samples.

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Acknowledgements

There is no financial support for this work. We are particularly grateful for the contribution of our Thyroid Breast Surgery colleagues at The Affiliated Hospital of Inner Mongolia Medical University.

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  1. Department of Thyroid Breast Surgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China

    Rina Guo & Rui Zhang

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R.G. collected materials, wrote, and revised this manuscript; R.Z. conceived and revised the manuscript. All authors have read and agreed to the published version of the manuscript.

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Guo, R., Zhang, R. Dual effects of circRNA in thyroid and breast cancer. Clin Transl Oncol 25, 3321–3331 (2023). https://doi.org/10.1007/s12094-023-03173-x

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