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A multi-center cross-sectional investigation of the diagnosis and treatment of breast cancer with synchronous ipsilateral supraclavicular lymph node metastases based on the CSBrs-009

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Abstract

Background

The diagnosis and management of breast cancer with ipsilateral supraclavicular lymph node metastases currently lack any applicable criteria or guidelines (ISLM), and diagnostic and treatment strategies are varied by medical centers. This study aimed to determine the current status of the diagnosis and treatment of breast cancer with ISLM among Chinese patients.

Methods

Data from 30 hospitals on ISLM breast cancer patients between January 1, 2018, and December 31, 2018, were systematically analyzed for the detection rate, clinicopathological characteristics, diagnosis and treatment strategies of breast cancer with ISLM among Chinese patients.

Results

A total of 26,723 women presented with breast cancer in 30 hospitals over the study period. A total of 127 ISLM breast cancer patients were finally enrolled. Synchronous ISLM without distant metastases was present in 0.48% of cases. The diagnosis of patients with 86.6% of ISLM was based on ultrasound examinations. The proportion of ISLM diagnosed by fine-needle aspiration biopsy (FNA) or core-needle biopsy (CNB) before surgery was 16.5% and 37.0%, respectively. Moreover, 45.7% of the ISLM patients had no pathological evidence. Regarding treatment strategies, 69.3% of ISLM patients received neoadjuvant chemotherapy (NAC) for more than 4 cycles, while 15.7% of patients did not receive NAC. 86.6% of ISLM patients underwent a mastectomy, and breast-conserving surgery was performed in 3.9% of ISLM patients. Moreover, 41.7% of ISLM patients received supraclavicular lymph node dissection (SCLD), while 47.2% were not treated with SCLD.

Conclusions

The overall detection rate of breast cancer in patients with ISLM is low in China and varies widely between hospitals. There is no consensus on the optimal diagnosis and treatment of patients with ISLM breast cancer.

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All data generated or analysed during this study are included in this published article.

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Acknowledgements

Thanks to the upfront members of Chinese Society of Breast Surgery for providing ISLM breast cancer patient data. Participants and researchers in this study（In no particular order: Beijing Chaoyang Hospital, Chuanhong Jiang. Peking University First Hospital, Yinhua Liu and Xuening Duan. Peking University People’s Hospital, Shu Wan. Beijing Friendship Hospital, Xiang Qu. The Second Affiliated Hospital of Dalian Medical University, Zuowei Zhao. The Affiliated Union Hospital of Fujian Medical University, Chuan Wang. The Obstetrics & Gynecology Hospital of Fudan University, Kejin Wu. Zhongshan Hospital Affiliated to Fudan University, Wei Zhu. Huashan Hospital of Fudan University, Qiang Zou. Wudang Hospital of Guizhou Medical University, Dahua Mao. The Second Affiliated Hospital of Harbin Medical University, Jianguo Zhang. Hebei Cancer Hospital, Zhenzhen Liu. The First Hospital of Jilin University, Zhimin Fan. Jilin Cancer Hospital, Ke Liu. The First Affiliated Hospital of the Air Force Military Medical University, Rui Ling. The Second Hospital of Lanzhou University, Ailin Song. The First Affiliated Hospital of the Army Military Medical University, Jun Jiang. The Inner Mongolia Autonomous Region Peoples Hospital, Zhongwei Cao. The Second Hospital of Shandong University, Zhigang Yu. Qilu Hospital of Shandong University, Rong Ma. Xuanwu Hospital of the Capital Medical University, Hua Kang. Sichuan Provincial People’s Hospital, Jinping Liu. The Affiliated Tumor Hospital of Xinjiang Medical University, Jianghua Ou. Yunnan Cancer Hospital, Dedian Chen. The Second Affiliated Hospital of Zhejiang University, Jian Huang. The First Affiliated Hospital of Zhejiang University, Peifen Fu. The General Hospital of People's Liberation Army, Jiandong Wang. The First Affiliated Hospital of China Medical University, Feng Jin. Sheng Jing Hospital Affiliated to China Medical University, Yi Zhao. Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Erwei Song.

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Authors and Affiliations

  1. Department of Thyroid and Breast Surgery, The General Hospital of Western Theater Command, Chengdu, 610083, Sichuan, China

    Xiang Ai & Peng Sun

  2. Breast Disease Center, Southwest Hospital, The Army Military Medical University, 30 Gaotanyan Road, Chongqing, 400038, China

    Minghao Wang, Peng Tang & Jun Jiang

  3. Sichuan Provincial People’s Hospital, Chengdu, 610072, Sichuan, China

    Jinping Liu

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  1. Xiang Ai
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Correspondence to Jun Jiang.

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Ai, X., Sun, P., Wang, M. et al. A multi-center cross-sectional investigation of the diagnosis and treatment of breast cancer with synchronous ipsilateral supraclavicular lymph node metastases based on the CSBrs-009. Clin Transl Oncol 25, 1482–1487 (2023). https://doi.org/10.1007/s12094-022-03053-w

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