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HIPEC with CRS versus cytoreductive surgery (CRS) for the gastric cancer metastasis to peritoneum

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Abstract

Background

Peritoneal metastases (PM) have a poor prognosis in gastric cancer (GC). Cytoreductive surgery (CRS) gives favorable outcomes, but the influence of hyperthermic intraperitoneal chemotherapy (HIPEC) remains contentious. We designed to distinguish results between CRS versus HIPEC-CRS in patients with peritoneal metastases from gastric cancer.

Materials and methods

PubMed, Scopus, Embase and Cochrane library accessed to collect data and language is restricted to English. RevMan 5.4 was used to perform statistical analysis. The outcomes for categorical variables are mentioned in the risk ratio.

Results

Ten trials involving 1367 patients in which 707 were CRS-HIPEC, while 660 CRS. We got significant results in 3rd year survival (P < 0.05), while 1st and 5th years are not statistically significant P > 0.05.

Conclusion

To compare with CRS, CRS-HIPEC has improved survival rate in deprived of further morbidity or mortality.

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Availability of data and materials

The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.

Abbreviations

PM:

Peritoneal metastases

GC:

Gastric cancer

CRS:

Cytoreductive surgery

HIPEC:

Hyperthermic intraperitoneal chemotherapy

RCTs:

Randomized controlled trials

NRCTs:

Non-randomized controlled trials

CI:

Confidence interval

RR:

Risk ratios

MD:

Mean difference

MMC:

Mitomycin

CDDP:

Cis-Diaminodichloroplatinum

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Acknowledgements

I'd like to thank all the authors for their outstanding work and contributions, particularly Chaohui Wang for revision and funding.

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Author notes

  1. Zhuming Chen and Muhammad Ali have equally contributed to this study.

Authors and Affiliations

  1. Department of General Surgery, Anqing First People’s Hospital of Anhui Medical University, Hefei, China

    Zhuming Chen, Zhe Kai & Chaohui Wang

  2. Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China

    Muhammad Ali & Yang Wang

  3. Medical College of Yangzhou University, Yangzhou, 225001, China

    Muhammad Ali & Yang Wang

Authors
  1. Zhuming Chen
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  2. Muhammad Ali
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  3. Zhe Kai
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  4. Yang Wang
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  5. Chaohui Wang
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Contributions

Muhammad Ali and Zhuming Chen write the manuscript and participate in data analysis, while Zhe Kai and Yang Wang helped in data collection under Chaohui Wang supervision and guidance in the manuscript draft.

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Correspondence to Chaohui Wang.

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Chen, Z., Ali, M., Kai, Z. et al. HIPEC with CRS versus cytoreductive surgery (CRS) for the gastric cancer metastasis to peritoneum. Clin Transl Oncol 25, 1011–1016 (2023). https://doi.org/10.1007/s12094-022-03004-5

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  • DOI: https://doi.org/10.1007/s12094-022-03004-5

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