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A research review of experimental animal models with myelodysplastic syndrome

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Abstract

Myelodysplastic syndrome (MDS) consists of a group of hematologic tumors that are derived from the clonal proliferation of hematopoietic stem cells, featuring abnormal hematopoietic cell development and ineffective hematopoiesis. Animal models are an important scientific research platform that has been widely applied in the research of human diseases, especially tumors. Animal models with MDS can simulate characteristic human genetic variations and tumor phenotypes. They also provide a reliable platform for the exploration of the pathogenesis and diagnostic markers of MDS as well as for a drug efficacy evaluation. This paper reviews the research status of three animal models and a new spontaneous mouse model with MDS.

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Data availability

The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request. We declared that materials described in the manuscript, including all relevant raw data will be freely available to any scientist wishing to use them for non-commercial purposes, without breaching participant confidentiality.

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Acknowledgements

We would like to acknowledge the hard and dedicated work of all the staff who implemented the intervention and evaluation components of the study.

Funding

This work was supported by Young and Middle-aged Teachers Education Research Project of Fujian Province (Technology) (No. JAT210104).

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Author notes

  1. Gen‑Wang Chen and Mei-Na Chen have contributed equally to this study.

Authors and Affiliations

  1. Clinical Lab and Medical Diagnostics Laboratory, Donghai Hospital District, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China

    Gen-Wang Chen, Lei Liu, Yu-Yu Zheng, Jin-Peng Wang, Si-Si Gong, Rong-Fu Huang & Chun-Mei Fan

  2. Clinical Lab, Quanzhou Hospital of Traditional Chinese Medicine, Quanzhou, 362000, China

    Mei-Na Chen & Yue-Zu Chen

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  1. Gen-Wang Chen
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Contributions

Conception and design of the research: GWC and CMF. Writing of the manuscript: GWC and MNC. Critical revision of the manuscript for intellectual: CMF, YZC, LL, YYZ, JPW, SSG, and RFH. All the authors read and approved the final draft.

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Correspondence to Chun-Mei Fan.

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Chen, GW., Chen, MN., Liu, L. et al. A research review of experimental animal models with myelodysplastic syndrome. Clin Transl Oncol 25, 105–113 (2023). https://doi.org/10.1007/s12094-022-02931-7

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