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The role of LncRNA MCM3AP-AS1 in human cancer

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Abstract

Long noncoding RNAs (lncRNA) play pivotal roles in every level of gene and genome regulation. MCM3AP-AS1 is a lncRNA that has an oncogenic role in several kinds of cancers. Aberrant expression of MCM3AP-AS1 has been reported to be involved in the progression of diverse malignancies, including colorectal, cervical, prostate, lymphoma, lung, ovary, liver, bone, and breast cancers. It is generally believed that MCM3AP-AS1 expression is associated with cancer cell growth, proliferation, angiogenesis, and metastasis. MCM3AP-AS1 by targeting various signaling pathways and microRNAs (miRNAs) presents an important role in cancer pathogenesis. MCM3AP-AS1 as a competitive endogenous RNA has the ability to sponge miRNA, inhibit their expressions, and bind to different target mRNAs related to cancer development. Therefore, MCM3AP-AS1 by targeting several signaling pathways, including the FOX family, Wnt, EGF, and VEGF can be a potent target for cancer prediction and diagnosis. In this review, we will summarize the role of MCM3AP-AS1 in various human cancers.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

AGGF1:

Angiogenic factor with G-patch and FHA domain 1

BL:

Burkitt lymphoma

BC:

Breast cancer

CENPF:

Centromere protein F

CSCC:

Squamous cell carcinoma

CDK:

Cyclin-dependent kinase

CCND1:

Cyclin D1

ccRCC:

Clear cell renal cell carcinoma

ceRNA:

Competing endogenous

CRC:

Colorectal cancer

DDK:

Dbf4 dependent kinase

DPP:

Dipeptidyl peptidase

EIF4E:

Eukaryotic translation initiation factor 4E

ER:

Estrogen receptor

EC:

Endometrial cancer

EMT:

Epithelial–mesenchymal transition

Erα:

Estrogen receptor α

FOXF2:

Forkhead box F2

GBM:

Glioblastoma

GC:

Gastric cancer

HCC:

Hepatocellular carcinoma

HPV:

Human papillomavirus

lncRNA:

Long noncoding RNAs

miRNAs:

MicroRNAs

MCM:

Minichromosome maintenance protein

MMP1:

Matrix metalloproteinase 1

NHL:

Non-Hodgkin lymphoma

ORC:

Origin recognition complex

OSCC:

Oral squamous cell carcinoma

OC:

Ovarian cancer

pre-RC:

Pre-replicative complex

PARP:

Poly (ADP-ribose) polymerase 1

PaC:

Pancreatic cancer

PTC:

Papillary thyroid cancer

PrC:

Prostate cancer

PR:

Progesterone receptor

RCC:

Renal cell carcinoma

SPARC:

Secreted protein acidic and cysteine rich

TAK1:

Transforming growth factor‑β‑activated kinase 1

VEGF-A:

Vascular endothelial growth factor-A

ZFP36:

RNA-binding protein ZFP36 ring finger protein

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Authors and Affiliations

  1. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Shirin Azizidoost

  2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Farhoodeh Ghaedrahmati

  3. Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mohadeseh Sheykhi-Sabzehpoush, Mehri Ghafourian & Abdolah Mousavi Salehi

  4. Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar

    Shahab Uddin

  5. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mehri Ghafourian & Maryam Farzaneh

  6. Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mona Keivan

  7. Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Maryam Cheraghzadeh & Zahra Nazeri

  8. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Seyed Esmaeil Khoshnam

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SHA, FGH, MSH, SHU, MGH, AM, MK, MCH, and ZN have made contributions to the writing of the manuscript. SE. KH., and M. F. have made contributions to the design of the figure and the revision of the manuscript. All authors have approved the submitted version of the article and have agreed to be personally accountable for the author’s own contributions and to ensure that questions related to the accuracy or integrity of any part of the work. All authors read and approved the final manuscript.

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Azizidoost, S., Ghaedrahmati, F., Sheykhi-Sabzehpoush, M. et al. The role of LncRNA MCM3AP-AS1 in human cancer. Clin Transl Oncol 25, 33–47 (2023). https://doi.org/10.1007/s12094-022-02904-w

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