Abstract
Purpose
The purpose of this study is to explore the application value of CDFI and SMI combined with serological markers in distinguishing benign and malignant thyroid nodules.
Method
A total of 192 patients with thyroid nodules admitted to our hospital from July 2019 to December 2020 were selected as subjects. Color Doppler blood flow imaging (CDFI) and supermicro blood flow imaging (SMI) methods are used to detect the blood flow of patients and the levels of serum thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), and thyroid stimulating hormone (TSH). The receiver operating characteristic curve (ROC curve) was used to observe the sensitivity and specificity of serological markers for distinguishing benign and malignant thyroid nodules, and combined with CDFI and SMI to observe the sensitivity and specificity for distinguishing benign and malignant thyroid nodules.
Results
The levels of TgAb, TPOAb and TSH in benign thyroid nodules were lower than those of the malignant group, and the difference was statistically significant (P < 0.01). There was no statistically significant difference between benign and malignant thyroid nodules in the presence or absence of the capsule and the presence or absence of vocal halo (P > 0.05), while the differences in the nodule morphology, boundary, internal echo and internal calcification were statistically significant (P < 0.01).
Conclusion
CDFI and SMI combined with serological index detection have higher value in the differential diagnosis of thyroid cancer, which can significantly improve the sensitivity and specificity of differential diagnosis.
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FL conceived and designed the study, and drafted the manuscript. WS and LL collected, analyzed and interpreted the experimental data. ZM and JS revised the manuscript for important intellectual content. All authors read and approved the final manuscript.
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The study was approved by Ethical Committee of Yantaishan Hospital and conducted in accordance with the ethical standards.
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Li, F., Sun, W., Liu, L. et al. The application value of CDFI and SMI combined with serological markers in distinguishing benign and malignant thyroid nodules. Clin Transl Oncol 24, 2200–2209 (2022). https://doi.org/10.1007/s12094-022-02880-1
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DOI: https://doi.org/10.1007/s12094-022-02880-1