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BAG family proteins contributes to autophagy-mediated multidrug resistance of tumor

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Abstract

Multidrug resistance (MDR) is a significant cause of tumor treatment failure. Accumulating evidence suggests that autophagy plays a significant role in the development of MDR. Autophagy is a conserved mechanism that maintains tumor homeostasis by removing damaged mitochondria. However, the specific regulatory mechanism is unclear. Here, we summarize recent studies on the role of autophagy in the development of MDR and the initiation of mitophagy by Bcl-2-associated athanogene (BAG) family proteins. Additionally, this mini-review emphasizes the regulatory role of BAG family proteins, which maintain mitochondrial homeostasis by regulating the PINK1/Parkin pathway. Elucidation of the regulatory mechanisms of mitophagy may foster the development of clinical therapeutic strategies for MDR tumors.

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Acknowledgements

We thank all the people in the lab for critical discussion, and we thank them for the funding for this study.

Funding

This work was funded by the Project of Maternal and Child Health Center of China Center for Disease Control and Prevention, grant number 2020FYH019, and the Project of Chengdu Municipal Health Commission, Grant number 2020211.

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  1. Jufang Guo and Xuelian Du have contributed equally to this work and should be considered co-first authors.

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  1. Department of Obstetrics and Gynecology, Jinniu District Maternal and Child Health Hospital, Chengdu, China

    Jufang Guo, Xuelian Du & Chaolin Li

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  1. Jufang Guo
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  2. Xuelian Du
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  3. Chaolin Li
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Conception and design: CL and XD; writing: JG; revision of the manuscript: CL. All authors read and approved the final manuscript.

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Correspondence to Chaolin Li.

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Guo, J., Du, X. & Li, C. BAG family proteins contributes to autophagy-mediated multidrug resistance of tumor. Clin Transl Oncol 24, 1492–1500 (2022). https://doi.org/10.1007/s12094-022-02819-6

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