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Stereotactic body radiotherapy for early-stage non-small cell lung cancer: a multicentre study by the Oncologic Group for the Study of Lung Cancer (Spanish Radiation Oncology Society)

Clinical and Translational Oncology volume 24, pages 342–349 (2022)Cite this article

Abstract

Purpose/objective(s)

Stereotactic body radiotherapy (SBRT) has become the standard of care for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC) and for patients who refuse surgery. The aim of this study was to evaluate the effectiveness and safety of primary SBRT in patients with early-stage NSCLC.

Materials/methods

Retrospective multicenter study of 397 patients (416 primary lung tumours) treated with SBRT at 18 centres in Spain. 83.2% were men. The median age was 74.4 years. In 94.4% of cases, the tumour was inoperable. The pathological report was available in 54.6% of cases. SPSS vs 22.0. was used to perform all statistical analyses.

Results

Complete response was obtained in 53.6% of cases. Significant prognostic factors were standard CT planning (p = 0.014) and 4D cone beam CT (p = 0.000). Acute and chronic toxicity ≥ grade 3 was observed in 1.2% of cases. At a median follow-up of 30 months, local relapse was 9.6%, lymph node relapse 12.8%, distant metastasis 16.6%, and another lung tumour 11.5%. Complete response was the only significant prognostic factor for local relapse (p = 0.012) and distant metastasis (p = 0.001). The local relapse-free survival was 88.7%. The overall survival was 75.7%. The cancer-specific survival was 92.7%. The disease-free survival was 78.7%.

Conclusion

SBRT is an effective and well-tolerated treatment option for patients with early-stage lung cancer who are not suitable for surgery. The most important prognostic factor for local and distant recurrence was complete response, which in our sample depended on the type of CT planning and the IGRT technique.

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Authors and Affiliations

  1. Hospital Universitario Rey Juan Carlos, Móstoles, Spain

    P. Mª Samper Ots & E. Amaya Escobar

  2. Hospital Universitario Ramón y Cajal, Madrid, Spain

    C. Vallejo Ocaña & M. Martin Martin

  3. Hospital Universitario y Politécnico La Fe, Valencia, Spain

    F. J. Celada Álvarez & D. Farga Albiol

  4. Hospital General de Valencia, Valencia, Spain

    P. Almendros Blanco & A. Hernandez Machancoses

  5. Complejo Hospitalario de Navarra, Navarra, Spain

    M. Rico Oses & S. Flamarique Andueza

  6. Hospital Universitario Reina Sofía, Córdoba, Spain

    F. Romero Ruperto & C. Maria Bueno

  7. Hospital La Luz Madrid Quironsalud Madrid, Madrid, Spain

    L. L. Guerrero Gómez

  8. Hospital Universitario Quironsalud y Hospital La Luz Quironsalud, Madrid, Spain

    F. Couñago

  9. Hospital Universitario Clínico San Carlos, Madrid, Spain

    Mª del Pino Alcántara

  10. Hospital Universitario La Paz, Madrid, Spain

    Mª J. Ruiz Villar

  11. Hospital Universitario de la Rivera, Alcira, Valencia, Spain

    J. L. Monroy Antón

  12. Hospital Universitario Central de la Defensa “Gómez Ulla”, Madrid, Spain

    P. Saez Bueno

  13. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain

    J. Luna Tirado

  14. Hospital Universitario Miguel Servet, Zaragoza, Spain

    Mª del Mar Puertas

  15. Hospital Ruber Internacional, Madrid, Spain

    A. Bobo

  16. Hospital Universitario Marques de Valdecilla, Santander, Spain

    I. Diaz de Cerio Martínez

  17. Hospital Universitario 12 de Octubre, Madrid, Spain

    N. Gascon Costoso

  18. Complejo Hospitalario Castellón, Castellón, Spain

    C. Ferrer Albiach

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  1. P. Mª Samper Ots
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  2. C. Vallejo Ocaña
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Corresponding author

Correspondence to P. Mª Samper Ots.

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The study was approved by the Clinical Research Ethics Committees of all participating institutions and complied with all data protection regulations.

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Samper Ots, P.M., Vallejo Ocaña, C., Martin Martin, M. et al. Stereotactic body radiotherapy for early-stage non-small cell lung cancer: a multicentre study by the Oncologic Group for the Study of Lung Cancer (Spanish Radiation Oncology Society). Clin Transl Oncol 24, 342–349 (2022). https://doi.org/10.1007/s12094-021-02697-4

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Keywords

  • SBRT
  • Lung cancer
  • Prognostic factors