Abstract
Purpose
To investigate the expression of bone morphogenetic protein 10 (BMP-10) in patients with endometrial carcinoma (EC) and its clinical significance.
Methods
Totally 143 cancer tissue specimens were sampled from patients with EC and retrospectively analyzed. The immunohistochemical method was adopted for quantifying BMP-10 in EC tissues. Then the patients were assigned to high and low BMP-10 expression groups. The Kaplan–Meier method and log-rank test were adopted to compare the difference of tumor-free survival (TFS) rate and overall survival (OS) rate between the two groups. The COX proportional hazard model was used to analyze independent risk factors affecting the TFS rate and OS rate of patients with EC.
Results
There were 80 patients (55.94%) with low BMP-10 expression and 63 patients with high BMP-10 expression (54.06%). BMP-10 expression was significantly correlated with International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.001), myometrial invasion depth (P < 0.001), histological grade (P < 0.001), and lymph node metastasis (P = 0.009). Additionally, TFS rate (P = 0.004) and OS rate (P = 0.003) in the low BMP-10 expression group were notably lower than those in the high BMP-10 expression group. Multivariate analysis showed that BMP-10 expression (HR: 13.712, 95% CI 1.823–103.158, P = 0.011) was an independent risk factor for the TFS of patients with EC. FIGO stage (P = 0.001) and BMP-10 expression (HR: 8.655, 95% CI 1.098–68.215, P = 0.020) were independent risk factors for the OS of such patients.
Conclusions
BMP-10 can be adopted as a molecular marker for predicting the poor prognosis of patients with EC.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5–29.
Bartosch C, Gomes B, Jerónimo C, Lopes JM. Endometrial carcinoma in Portugal: demographic, diagnostic and treatment changes in the last 5 decades. Int J Gynecol Pathol. 2015;34:159–68.
Brazil DP, Church RH, Surae S, Godson C, Martin F. BMP signalling: agony and antagony in the family. Trends Cell Biol. 2015;25:249–64.
Hu M, Cui F, Liu F, Wang J, Wei X, Li Y. BMP signaling pathways affect differently migration and invasion of esophageal squamous cancer cells. Int J Oncol. 2017;50:193–202.
Huang P, Chen A, He W, et al. BMP-2 induces EMT and breast cancer stemness through Rb and CD44. Cell Death Discov. 2017;3:17039.
Yokoyama Y, Watanabe T, Tamura Y, Hashizume Y, Miyazono K, Ehata S. Autocrine BMP-4 signaling is a therapeutic target in colorectal cancer. Cancer Res. 2017;77:4026–38.
Lei H, Wang J, Lu P, et al. BMP10 inhibited the growth and migration of gastric cancer cells. Tumour Biol. 2016;37:3025–31.
Wu M, Chen W, Mi J, Chen D, Wang W, Gao H. Expression analysis of BMP2, BMP5, BMP-10 in human colon tissues from Hirschsprung disease patients. Int J Clin Exp Pathol. 2014;7:529.
Zhang N, Ye L, Wu L, Deng X, Yang Y, Jiang WG. Expression of bone morphogenetic protein-10 (BMP10) in human urothelial cancer of the bladder and its effects on the aggressiveness of bladder cancer cells in vitro. Anticancer Res. 2013;33:1917–25.
Penzel R, Hoegel J, Schmitz W, et al. Clusters of chromosomal imbalances in thymic epithelial tumours are associated with the WHO classification and the staging system according to Masaoka. Int J Cancer. 2003;105:494–8.
Bradford LS, Rauh-Hain JA, Schorge J, Birrer MJ, Dizon DS. Advances in the management of recurrent endometrial cancer. Am J Clin Oncol. 2015;38:206–12.
Gao J, Yang G, Wen W, et al. Impact of known risk factors on endometrial cancer burden in Chinese women. Eur J Cancer Prev. 2016;25:329.
Shen W, Pang H, Xin B, Duan L, Liu L, Zhang H. Biological effects of BMP7 on small-cell lung cancer cells and its bone metastasis. Int J Oncol. 2018;53:1354–62.
Deng G, Zeng S, Qu Y, et al. BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation. J Exp Clin Cancer Res. 2018;37:156.
Gou L, Liu M, Xia J, et al. BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1. Int J Mol Sci. 2018;19:1116.
Deane JA, Cousins FL, Gargett CE. Endometrial organoids: in vitro models for endometrial research and personalized medicine. Biol Reprod. 2017;97:781–3.
Jin Y, Zheng W, Li L, et al. Loss of BMP-10 is correlated with poor survival in ovarian cancer. Pathol Res Pract. 2019;215:121–6.
Author information
Authors and Affiliations
Contributions
YaH, LY, and LX conceived and designed the study, and drafted the manuscript. LaH, FX, FL, CC, and YuH collected, analyzed, and interpreted the experimental data. LY, FX, and LX revised the manuscript for important intellectual content. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
The study was approved by Ethical Committee of The Central Hospital of Wuhan and conducted in accordance with the ethical standards.
Informed consent
Subjects signed the informed consent.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Hu, Y., Yu, L., Xia, F. et al. Expression of bone morphogenetic protein 10 in cases with endometrial carcinoma and its clinical significance. Clin Transl Oncol 23, 1711–1716 (2021). https://doi.org/10.1007/s12094-021-02572-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12094-021-02572-2