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Stereotactic body radiation therapy for liver metastasis from colorectal cancer: size matters

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Abstract

Purpose

We analysed our initial experience with SBRT in liver metastasis from colorectal cancer at our institution.

Materials and methods

Between January/2014 and December/2017, 22 patients with 31 LMCCR were treated. Local control (LC) was assessed using the Kaplan–Meier and log-rank tests. We analysed potential prognostic factors for LC: sex, PTV size, number of LM and the radiation scheme.

Results

Median age: 69 years. Prior chemotherapy or local liver treatments: 81.8% and 63.6% of patients, respectively. SBRT consisted of 3 × 20 Gy (42.9%) and 3 × 15 Gy (31.4%). There were 88.5% responses (57.1% CR and 31.4% PR). Median follow-up was 30 months. LC per lesion at 12 and 24 months was 85.3% and 61.8%, respectively. Tumour volumes > 30 cc correlated with worsened 2-year-control rates (90% vs 34.5%) (p = 0.005). There was only a patient with CTC-grade 3 toxicity.

Conclusions

Liver SBRT is a safe and effective treatment that achieves high local control rates. We found a significant correlation between larger LMCRC and worse local control.

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Authors and Affiliations

  1. Radiation Oncology Department, Complejo Hospitalario de Navarra, Navarre, Spain

    S. Flamarique, M. Campo, G. Asín, S. Pellejero, A. Viúdez & F. Arias

  2. Medical Oncology Department, Complejo Hospitalario de Navarra, Navarre, Spain

    A. Viúdez

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  1. S. Flamarique
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  2. M. Campo
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  3. G. Asín
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Correspondence to F. Arias.

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Flamarique, S., Campo, M., Asín, G. et al. Stereotactic body radiation therapy for liver metastasis from colorectal cancer: size matters. Clin Transl Oncol 22, 2350–2356 (2020). https://doi.org/10.1007/s12094-020-02375-x

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  • DOI: https://doi.org/10.1007/s12094-020-02375-x

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