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Prognostic role of interleukin-6 in renal cell carcinoma: a meta-analysis

  • Y. WangEmail author
  • Y. Zhang
Research Article
  • 48 Downloads

Abstract

Background

To evaluate the prognostic role of interleukin-6 (IL-6) in renal cell carcinoma (RCC).

Method

Relevant research articles were obtained from literature databases. Data were extracted from study reports which reported IL-6 levels in relevance to RCC prognosis and random-effects meta-analyses were performed to estimate IL-6 levels, percentage of patients with high IL-6 levels, and hazard/odds ratios between high and low IL-6 levels in survival outcomes.

Results

22 studies (1976 patients; age 59.9 years [95% confidence interval (CI) 58.0, 61.8]; 33% [95% CI 29, 36] females) were included. IL-6 levels in RCC patients ranged from 8.9 ± 13–193 ± 101 picograms per milliliter (pg/ml) which were higher than those of normal healthy individuals (mean difference 13.96 pg/ml [95% CI: 1.52, 26.40]; p = 0.03). Percentage of RCC patients with high IL-6 levels was 48.98% [95% CI 42.94, 55.03] and this rate was greater in advanced (51.73% [95% CI 45.94, 57.53]) than in local (40.75% [95% CI 26.23, 55.27]) RCC. Survival was longer in patients with low compared to high IL-6 levels (MD 9.65 months [95% CI 5.01, 14.29]; p < 0.0006 and hazard ratio 3.03 [95% CI 2.37, 3.70]). Treatment response rate was significantly higher in patients with low IL-6 than high IL-6 levels (odds ratio 5.11 [95% CI 2.21, 11.77]; p < 0.00001). There was a strong correlation between IL-6 and c-reactive protein levels (correlation coefficient 0.622 [95% CI 0.431, 0.760]; p = 0.00001).

Conclusion

IL-6 levels are much variable in RCC patients. High levels of IL-6 in RCC patients are associated with poor survival.

Keywords

Renal cell carcinoma Interleukin-6 Prognosis Metastasis Survival 

Notes

Funding

None.

Compliance with ethical standards

Conflict of interest

All the authors have declared that they have no conflict of interest.

Research involving human participants and/or animals

All analyses were based on previous published studies, thus no ethical approval required.

Informed consent

For this type of study, formal consent is not required.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2019

Authors and Affiliations

  1. 1.Department of Urologic SurgeryYantai Affiliated Hospital of Binzhou Medical UniversityYantaiChina
  2. 2.Office of Quality Assurance and Safety ManagementYantai Affiliated Hospital of Binzhou Medical UniversityYantaiChina

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