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Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience

Abstract

Background

Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department.

Methods

Between June 2015 and June 2017, 106 patients and a total of 159 tumor lesions were included in a prospective study (EudraCT 2018-001089-40) of HT concomitant with radiotherapy (RT). Systemic treatment was accepted. HT was given twice a week, 60 min per session, during RT treatment by a regional capacitive device (HY-DEEP 600WM system) at 13.56 MHz radiofrequency.

Results

Most lesions (138 cases, 86.8%) received all HT sessions planned. Thirteen lesions (12 patients) withdrew treatment due to grade ≥3 QMHT toxicity. All these 12 patients completed the prescribed radiotherapy and/or systemic treatment.

Conclusions

Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment.

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Correspondence to M. Lloret.

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All human studies have been approved by the appropriate ethics committee and have, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Lloret, M., García-Cabrera, L., Hernandez, A. et al. Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience. Clin Transl Oncol 21, 1771–1775 (2019). https://doi.org/10.1007/s12094-019-02097-9

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Keywords

  • Hyperthermia
  • Radiotherapy
  • Advanced tumors