Cell-free DNA and preoperative chemoradiotherapy for rectal cancer: a systematic review
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Preoperative chemoradiotherapy is the standard of care for patients with locally advanced rectal cancer, yet valid circulating biomarkers are lacking. We aimed at systematically reviewing the literature of cell-free DNA and locally advanced rectal cancer.
A systematic literature search was performed. We retrieved papers reporting a correlation between a clinical outcome and cell-free DNA for patients receiving chemoradiotherapy for locally advanced rectal cancer.
We included nine studies of a total of 615 patients. Only single-arm studies were identified, analyzing either the total level of cell-free DNA or tumor-specific DNA. Despite differences in the methodology and outcomes, eight of the nine studies showed a correlation between cell-free DNA and a clinical outcome.
Cell-free DNA might hold prognostic and predictive information for patients with locally advanced rectal cancer receiving preoperative chemoradiotherapy; although, firm conclusions are limited by the heterogeneity in this field.
KeywordsRectal cancer Cell-free DNA Chemoradiotherapy Systematic review
No funding was used for this systematic review.
Compliance with ethical standards
Conflict of interest
All authors declare no conflicts of interest.
Statement of human/animal participants
This study did not involve human participants or animals.
All participants provided informed consent prior to their participation.
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