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Clinical and Translational Oncology

, Volume 20, Issue 10, pp 1337–1344 | Cite as

Pathology findings and clinical outcomes after risk reduction salpingo-oophorectomy in BRCA mutation carriers: a multicenter Spanish study

  • L. Minig
  • S. Cabrera
  • R. Oliver
  • A. Couso
  • M. J. Rubio
  • S. Iacoponi
  • M. B. Martin-Salamanca
  • S. Carballo-Rastrilla
  • J. M. Cádenas-Rebollo
  • A. García-Garcia
  • B. Gil-Ibáñez
  • M. J. Juan-Fita
  • M. G. Patrono
Research Article

Abstract

Objective

To determine the incidence of serous tubal intraepithelial carcinoma (STIC) after risk reduction salpingo-oophorectomy(RRSO), and to describe oncological outcomes after RRSO.

Materials and methods

BRCA pathogenic mutation carriers who had undergone an RRSO were evaluated in this retrospective multicenter observational study. Patients were only included when fallopian tubes were analyzed following the protocol for Sectioning and Extensively Examining the FIMbria (SEE-FIM). Surgeries were performed between June 2010 and April 2017 at eight Spanish hospitals.

Results

A total of 359 patients met the inclusion criteria. STIC was diagnosed in 3 (0.8%) patients; one of them underwent surgical staging due to positive peritoneal washing, with absence of disease at the final pathology report. None of the three patients received adjuvant chemotherapy and were free of disease at last follow-up. Fallopian tube and ovarian carcinoma were diagnosed in 5 (1.4%) and 1 (0.3%), respectively. At a median (range) follow-up time of 29 (3–92) months, five patients had a newly diagnosed breast cancer. Other types of cancer, which were diagnosed during the follow-up time, included: serous primary peritoneal carcinoma (n = 1), serous endometrial carcinoma (n = 1), colon (n = 1), pancreas (n = 1), jaw (n = 1), and lymphoma (n = 1). Seven patients died due to different types of cancer: breast (n = 4), pancreas (n = 1), jaw (n = 1), and colon (n = 1).

Conclusion

The incidence of STIC after RRSO in BRCA mutation carriers is low (0.8%) and it presents an excellent oncological outcome. Patients after RRSO, however, run the risk to develop other types of cancer during follow-up and should be properly advised before the prophylactic surgery.

Keywords

BRCA Risk reduction salpingo-oophorectomy Serous tubal intraepithelial carcinoma Ovarian cancer Primary peritoneal carcinoma 

Notes

Acknowledgements

The authors want to thank Lara Vargas, MD (Gynecology Department, Sanatorio Allende, Córdoba, Argentina) for her contribution in the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

Ethical approval

The study was previously approved by the Internal Review Board in accordance with the ethical standards of the Helsinki Declaration of 1975, revised in 1983.

Informed consent

For this type of study formal consent was not required.

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2018

Authors and Affiliations

  • L. Minig
    • 1
  • S. Cabrera
    • 2
  • R. Oliver
    • 3
  • A. Couso
    • 4
  • M. J. Rubio
    • 5
  • S. Iacoponi
    • 6
  • M. B. Martin-Salamanca
    • 7
  • S. Carballo-Rastrilla
    • 8
  • J. M. Cádenas-Rebollo
    • 9
  • A. García-Garcia
    • 1
  • B. Gil-Ibáñez
    • 2
  • M. J. Juan-Fita
    • 10
  • M. G. Patrono
    • 11
  1. 1.Gynecology DepartmentInstituto Valenciano de Oncología (IVO)ValenciaSpain
  2. 2.Gynecology DepartmentHospital Universitario Vall d`HebronBarcelonaSpain
  3. 3.Gynecology DepartmentHospital UniversitarioMadridSpain
  4. 4.Gynecology DepartmentHospital Universitario Príncipe de Asturias de Alcalá de HenaresMadridSpain
  5. 5.Medical Oncology DepartmentHospital Universitario Reina SofíaCórdobaSpain
  6. 6.Gynecology DepartmentHospital Universitario QuirónMadridSpain
  7. 7.Gynecology DepartmentHospital Universitario de GetafeMadridSpain
  8. 8.Gynecology DepartmentComplejo Hospitalario Universitario Insular Materno-Infantil de Canarias (CHUIMI)Islas CanariasSpain
  9. 9.Department of Applied Mathematics and StatisticsCEU San Pablo UniversityMadridSpain
  10. 10.Medical Oncology DepartmentInstituto Valenciano de Oncología (IVO)ValenciaSpain
  11. 11.Gynecology DepartmentHospital Italiano de Buenos AiresBuenos AiresArgentina

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