Still a place for conventional histopathological analysis in the era of molecular medicine: predicting prognosis of resectable ductal pancreatic adenocarcinoma
- 46 Downloads
Our aim is to find features that define prognosis in surgically resected ductal pancreatic adenocarcinoma readily accessible in everyday practice.
Materials and methods
Longitudinal retrospective case series of pancreatic adenocarcinoma operated with a curative intent in a large tertiary hospital in Madrid between 2009 and 2015.
162 were enrolled. 40.8% survived less than 1 year. Multivariate Cox’s regression model revealed that gender, presence of symptoms, T and N stage independently influenced progression-free survival, while overall survival was determined by gender, smoking, presence of symptoms and N stage. Logistic regression analysis revealed that only symptoms at diagnosis could predict death, while gender, symptoms, histopathological type, vessel invasion, T stage and necrosis could independently predict recurrence.
Our series show that patients with symptomatic disease at the time of diagnosis and females showed a shorter progression-free and overall survival. We herein propose a regression model to predict outcome.
KeywordsPancreas Adenocarcinoma Surgical therapy Prognosis
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest for the present study.
The project has been reviewed and approved by the Ethical Committee for Research at Hospital Clínico San Carlos.
As no personal data are shown, the authors have asked the committee for a informed consent waiver in dead patients, which has been given to us.
- 13.Macías N, Sayagués JM, Esteban C, Iglesias M, González LM, Quiñones-Sampedro J, et al. Histologic tumor grade and preoperative biliary drainage are the unique independent prognostic factors of survival in pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy. J Clin Gastroenterol. 2018;52:e11–7.Google Scholar