Clinical and Translational Oncology

, Volume 20, Issue 7, pp 853–861 | Cite as

Preoperative plasma fibrinogen is associated with poor prognosis in esophageal carcinoma: a meta-analysis

  • G. Y. Lv
  • Y. Yu
  • L. An
  • X. D. Sun
  • D. W. Sun
Research Article



The aim of this meta-analysis was to investigate preoperative plasma fibrinogen (PPF) as a prognostic marker in esophageal carcinoma (EC) by meta-analysis.


Relevant studies were sought in the databases including Pubmed, Web of Science, Cochrane library, and Wanfang databases up to Oct 10th, 2017. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were used as effective value, and pooled HRs were synthesized by STATA 14.0 to assess the prognostic impact of PPF on EC patients.


A total of 8 studies with 2827 patients were collected in this meta-analysis. Our results revealed that high PPF was significantly associated with poor OS (HR = 1.90, 95% CI 1.56–2.33, P = 0.000; HR = 1.76, 95% CI 1.28–2.42, P = 0.000) and poor DFS (HR = 1.91, 95% CI 1.50–2.43, P = 0.000; HR = 1.51, 95% CI 1.16–1.97, P = 0.000) in EC patients from univariate and multivariate analysis results, respectively, which suggested that EC patients with high PPF will suffer from high postoperative mortality and recurrence rate.


High PPF was significantly associated with poor OS and DFS in EC patients. Fibrinogen can serve as a prognostic marker and even a future targeting molecule during the treatment of EC patients.


Preoperative plasma fibrinogen (PPF) Esophageal carcinoma (EC) Prognosis Meta-analysis 


Compliance with ethical standards

Conflict of interests

All the authors declare there is no conflict of interest in this research.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2017

Authors and Affiliations

  1. 1.Department of Hepatobiliary and Pancreatic SurgeryThe First Hospital of Jilin UniversityChangchunChina
  2. 2.Department of DermatologyChina-Japan Union Hospital of Jilin UniversityChangchunChina

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