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Clinical and Translational Oncology

, Volume 19, Issue 10, pp 1268–1275 | Cite as

Integration of radiotherapy and chemotherapy for abdominal lymph node recurrence in gastric cancer

  • J. Lee
  • H. I. Yoon
  • S. Y. Rha
  • W. J. Hyung
  • Y. C. Lee
  • J. S. Lim
  • H. S. KimEmail author
  • W. S. KoomEmail author
Research Article
  • 187 Downloads

Abstract

Purpose

Abdominal lymph node (ALN) recurrence in gastric cancer (GC) is rare and usually unresectable. We investigated the effects of integration of radiotherapy (RT) and chemotherapy against ALN recurrence in GC.

Methods

We retrospectively categorized GC patients with ALN recurrence treated between 2005 and 2013 into two groups: those treated with integration of RT and chemotherapy (RCT) and those who received systemic chemotherapy only (CT). The median follow-up period after ALN recurrence for all patients was 20 months.

Results

Of 53 patients, 31 and 22 were in the RCT and CT groups, respectively. Isolated distant failure (DF; 35.5%) without local progression (LP) was the dominant pattern of failure (POF) in the RCT group (median DF-free period, 26 months). LP followed by DF (31.8%) was the dominant POF in the CT group; LP (median LP-free period, 8 months) occurred 10 months earlier than DF (median DF-free period, 18 months). RCT patients had significantly longer median progression-free survival (PFS) compared to CT patients (25 vs. 8 months; P = 0.021). On multivariate analysis, treatment (CT vs. RCT) was an independent prognostic factor for PFS (hazard ratio 2.085; 95% confidence interval 1.073–4.050; P = 0.013).

Conclusions

Integration of RT and chemotherapy achieved long-term local control and prolonged PFS in GC patients with ALN recurrence. Local RT is feasible for treating isolated ALN recurrences.

Keywords

Gastric cancer Lymph node recurrence Radiotherapy Chemotherapy 

Notes

Acknowledgements

This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2015R1C1A2A01055617, Hyo Song Kim).

Compliance with ethical standards

Conflict of interest

The authors indicate no potential conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study, formal consent is not required.

Supplementary material

12094_2017_1665_MOESM1_ESM.docx (171 kb)
Supplementary material 1 (DOCX 171 kb)

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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2017

Authors and Affiliations

  • J. Lee
    • 1
    • 2
  • H. I. Yoon
    • 1
  • S. Y. Rha
    • 3
  • W. J. Hyung
    • 4
  • Y. C. Lee
    • 3
  • J. S. Lim
    • 5
  • H. S. Kim
    • 3
    Email author
  • W. S. Koom
    • 1
    Email author
  1. 1.Department of Radiation OncologyYonsei University College of MedicineSeoulRepublic of Korea
  2. 2.Department of Radiation OncologyInha University HospitalIncheonRepublic of Korea
  3. 3.Department of Internal MedicineYonsei University College of MedicineSeoulRepublic of Korea
  4. 4.Department of SurgeryYonsei University College of MedicineSeoulRepublic of Korea
  5. 5.Department of RadiologyYonsei University College of MedicineSeoulRepublic of Korea

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