Clinical and Translational Oncology

, Volume 19, Issue 9, pp 1079–1083 | Cite as

Role of TIM-3 in ovarian cancer

  • Y. XuEmail author
  • H. Zhang
  • Y. Huang
  • X. Rui
  • F. Zheng
Review Article


Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4+ and CD8+ T cells and other immunocytes. Overexpression of TIM-3 in innate immune cells has been found in certain types of tumor. The blockade of TIM-3 leads to sustained anti-tumor reactions. TIM-3 plays an inhibitive role for immunity in ovarian cancer. TIM-3 is involved in the development of various subtypes of ovarian cancer and thus has the potential to be a therapeutic target for treatment of ovarian cancer.


TIM-3 Ovarian cancer Blockade 



This work was supported by grants from Society Development Plans, Department of Science and Technology Changzhou (CJ20159018 to Yun Xu). Besides, we also would like to thank Dr. Xiaofei Zhang and Dr. Xiaodong Li for their help in revising the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

This review does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was not applicable in this review.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2017

Authors and Affiliations

  1. 1.Department of GynecologyThe Third Affiliated Hospital of Soochow UniversityChangzhouChina
  2. 2.Department of Epidemiology and Biostatistics, College of Public HealthUniversity of South FloridaTampaUSA

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