Clinical and Translational Oncology

, Volume 19, Issue 6, pp 750–760 | Cite as

Impact of clinicopathological parameters on survival after multiorgan resection among patients with T4 gastric carcinoma: a systematic review and meta-analysis

  • G. ZuEmail author
  • T. Zhang
  • W. Li
  • Y. Sun
  • X. ZhangEmail author
Research Article



The prognostic factors which can improve the overall survival (OS) of patients with T4 gastric carcinoma (GC) are still controversial: a meta-analysis was conducted to analyze the impact of clinicopathological parameters on survival after MOR among patients with T4 GC.


A systematic search was performed. Odd risks (ORs) of patients with T4 GC were used to calculate the relationship between clinicopathological parameters and OS.


Nine studies involving 941 patients with T4 GC were identified. Well-moderate differentiation led to increased 1-, 3-, 5-year OS with an OR of 2.63, 1.58 and 1.45. Borrmann type I–II led to increased 1-, 3-year OS with an OR of 1.67 and 2.08. No lymph node metastasis led to increased 1-, 3-, 5-year OS with an OR of 7.16, 3.18 and 3.71. Total gastrectomy led to increased 1-, 3-year OS with an OR of 2.01 and 1.79. ≥2 Organs resected led to increased 1-, 3-year OS with an OR of 2.19 and 2.19. TNM stage II–III led to increased 1-, 3-year OS with an OR of 3.68 and 5.75. Curative resection led to increased 1-, 3-, 5-year OS with an OR of 4.46, 5.80 and 5.98.


Well-moderate differentiation, Borrmann type I–II, no lymph node metastasis, total gastrectomy, ≥2 organs resected, TNM stage II–III and curative resection were positive prognostic factors for OS of patients with T4 GC.


Clinicopathological parameters Survival Multiorgan resection Gastric carcinoma 



G. Zu and X. Zhang designed the research; W. Li and T. Zhang conducted the research; W. Li and Y. Sun analyzed data; G. Zu wrote the draft; all authors read, reviewed and approved the final manuscript. G. Zu and X. Zhang had primary responsibility for final content.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2016

Authors and Affiliations

  1. 1.Department of Gastroenterology SurgeryThe Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalianPeople’s Republic of China

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